Effects of intra-hippocampal injections of the NK2 receptor antagonist saredutant on the elevated plus maze, and the mouse defense test battery

• Published in: Neuroscience letters Vol. 485; no. 3; pp. 241 - 245
• Main Authors: Borelli, Karina Genaro, Defensor, Erwin B., Blanchard, D. Caroline, Blanchard, Robert J., Griebel, Guy
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 26.11.2010; Elsevier
• Subjects: Animals; Anti-Anxiety Agents - administration & dosage; Anti-Anxiety Agents - pharmacology; Anxiety; Anxiety - psychology; Avoidance Learning - drug effects; Benzamides - administration & dosage; Benzamides - pharmacology; Biological and medical sciences; Cats; Defensive behavior; Escape Reaction - drug effects; Exploratory Behavior - drug effects; Fundamental and applied biological sciences. Psychology; Hippocampus - anatomy & histology; Hippocampus - physiology; Male; Mice; Microinjections; Odorants; Piperidines - administration & dosage; Piperidines - pharmacology; Rats; Rats, Long-Evans; Receptors, Neurokinin-2 - antagonists & inhibitors; Stereotaxic Techniques; Tachykinin NK2 receptor antagonist; Ventral hippocampus; Vertebrates: nervous system and sense organs; Ventral hippocampus; Anxiety; Tachykinin NK2 receptor antagonist; Defensive behavior; Saredutant; Rodentia; Central nervous system; Encephalon; Vertebrata; Mammalia; Mouse; Animal; NK2 Tachykinin receptor; Antagonist; Hippocampus

▶ Intra-ventral hippocampus of saredutant produced anxiolytic-like effects. ▶ Low dose of saredutant (10 pmol) reduced avoidance of the threat stimulus. ▶ Saredutant weakly modified defensive behaviors in mice confronted by a rat. ▶ Saredutant injected into the ventral hippocampus reduced the inhibi...