Leptin alters energy intake and fat mass but not energy expenditure in lean subjects

• Published in: Nature communications Vol. 11; no. 1; pp. 5145 - 15
• Main Authors: Chrysafi, Pavlina, Perakakis, Nikolaos, Farr, Olivia M., Stefanakis, Konstantinos, Peradze, Natia, Sala-Vila, Aleix, Mantzoros, Christos S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.10.2020; Nature Portfolio
• Subjects: 631/443/319; 692/163/2743; 82/16; 82/58; Humanities and Social Sciences; multidisciplinary; Science; Science (multidisciplinary)

Based on studies in mice, leptin was expected to decrease body weight in obese individuals. However, the majority of the obese are hyperleptinemic and do not respond to leptin treatment, suggesting the presence of leptin tolerance and questioning the role of leptin as regulator of energy balance in...