CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis

• Published in: Nature communications Vol. 11; no. 1; pp. 4765 - 16
• Main Authors: Hao, Jian-Wei, Wang, Juan, Guo, Huiling, Zhao, Yin-Yue, Sun, Hui-Hui, Li, Yi-Fan, Lai, Xiao-Ying, Zhao, Ning, Wang, Xu, Xie, Changchuan, Hong, Lixin, Huang, Xi, Wang, Hong-Rui, Li, Cheng-Bin, Liang, Bin, Chen, Shuai, Zhao, Tong-Jin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.09.2020; Nature Portfolio
• Subjects: 14/19; 631/45/287/1183; 631/80/313/2026; 631/80/86/2369; 82/1; 82/29; 82/58; 82/80; 96/1; 96/95; Humanities and Social Sciences; multidisciplinary; Science; Science (multidisciplinary)

Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in turn delivers FAs into adipocytes. During the process, binding of FAs to CD36 activates its downstream kinase LYN, whic...