Late Effects of Chronic Low Dose Rate Total Body Irradiation on the Heart Proteome of ApoE -/- Mice Resemble Premature Cardiac Ageing

• Published in: Cancers Vol. 15; no. 13; p. 3417
• Main Authors: Azimzadeh, Omid, Merl-Pham, Juliane, Subramanian, Vikram, Oleksenko, Kateryna, Krumm, Franziska, Mancuso, Mariateresa, Pasquali, Emanuela, Tanaka, 3rd, Ignacia B, Tanaka, Satoshi, Atkinson, Michael J, Tapio, Soile, Moertl, Simone
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.06.2023; MDPI
• Subjects: Aging; Apolipoprotein E; Apolipoproteins; Cardiovascular disease; Cardiovascular diseases; Confounding (Statistics); Dosimetry; Energy metabolism; Enzymatic activity; Enzymes; Epidemiology; Gamma rays; Glycolysis; Heart; Immunoblotting; Immunohistochemistry; Laboratory animals; Metabolism; Molecular modelling; Oxidative metabolism; Oxidative stress; Peptides; Proteins; Proteomes; Proteomics; Radiation; Risk assessment; Signal transduction; Software; TOR protein; Transcriptomics; Massachusetts; Germany; United States > US; Japan; cardiovascular disease; ageing; ionising radiation; proteomics; TGFβ; AMPK; TBI; chronic exposure; PPARα; SIRT; heart; oxidative stress

Recent epidemiologic studies support an association between chronic low-dose radiation exposure and the development of cardiovascular disease (CVD). The molecular mechanisms underlying the adverse effect of chronic low dose exposure are not fully understood. To address this issue, we have investigat...