Protein tyrosine phosphatase receptor type kappa (PTPRK) revisited: evolving insights into structure, function, and pathology

• Published in: Journal of translational medicine Vol. 23; no. 1; pp. 534 - 17
• Main Authors: Zheng, Chen, Liu, Ting, Wang, An Qi, Chen, Xing An, Zhang, Rong Zhe, Wang, Xuan Chao, Lv, Chao Yue, Pan, Ru Lu, Wang, Ou Chen, Lu, Xin-Cheng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.05.2025; BioMed Central; BMC
• Subjects: Analysis; Animals; Autoimmune diseases; Care and treatment; Development and progression; Genetic aspects; Genetic polymorphisms; Humans; Neoplasms - enzymology; Neoplasms - pathology; Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 2 - chemistry; Receptor-Like Protein Tyrosine Phosphatases, Class 2 - metabolism; Review; Signal Transduction; Structure-Activity Relationship; Tumor suppressor genes; China

Protein Tyrosine Phosphatase Receptor Type Kappa (PTPRK) is a membrane-bound tyrosine phosphatase encoded by the frequently deleted region of chromosome 6q, which plays a crucial role in regulating cell signaling, adhesion, and immune response. Structurally, PTPRK comprises with an extracellular dom...