Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats

• Published in: Bioscience reports Vol. 38; no. 5
• Main Authors: Zheng, Bin, Zhang, Shuncai, Ying, Yanlu, Guo, Xinying, Li, Hengchang, Xu, Lixin, Ruan, Xiangcai
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 31.10.2018
• Subjects: traumatic brain injury; NLRP3; inflammation; caspase-1; Dexmedetomidine

The abnormally high nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activity is a typical characteristic of traumatic brain injury (TBI). Dexmedetomidine (Dex) is a highly selective α-2 adrenergic receptor agonist that inhibits the...