FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1

• Published in: The Journal of cell biology Vol. 185; no. 3; pp. 439 - 457
• Main Authors: Norrmén, Camilla, Ivanov, Konstantin I, Cheng, Jianpin, Zangger, Nadine, Delorenzi, Mauro, Jaquet, Muriel, Miura, Naoyuki, Puolakkainen, Pauli, Horsley, Valerie, Hu, Junhao, Augustin, Hellmut G, Ylä-Herttuala, Seppo, Alitalo, Kari, Petrova, Tatiana V
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 04.05.2009; Rockefeller University Press
• Subjects: Animals; Basement Membrane - physiology; Binding sites; Blood vessels; Blood Vessels - physiology; Capillaries - physiology; Cells; Developmental biology; Embryos; Endothelial cells; Forkhead Transcription Factors - deficiency; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - physiology; Heart valves; Heart Valves - physiology; Lymphatic system; Lymphatic vessels; Lymphatic Vessels - pathology; Lymphatic Vessels - physiology; Mice; Mice, Knockout; NFATC Transcription Factors - physiology; Proteins; Skin Physiological Phenomena; Sprouting; Stem cells; T lymphocytes; Transcription factors

The mechanisms of blood vessel maturation into distinct parts of the blood vasculature such as arteries, veins, and capillaries have been the subject of intense investigation over recent years. In contrast, our knowledge of lymphatic vessel maturation is still fragmentary. In this study, we provide...