Role of TET enzymes in DNA methylation, development, and cancer
The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in diseases. The ten eleven translocation (TET) enzymes oxidize 5-methylcytosines (5mCs) and promote locus-specific reversal of DNA methylation. T...
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| Published in | Genes & development Vol. 30; no. 7; pp. 733 - 750 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Cold Spring Harbor Laboratory Press
01.04.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0890-9369 1549-5477 1549-5477 |
| DOI | 10.1101/gad.276568.115 |
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| Abstract | The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in diseases. The ten eleven translocation (TET) enzymes oxidize 5-methylcytosines (5mCs) and promote locus-specific reversal of DNA methylation.
TET
genes, and especially
TET2
, are frequently mutated in various cancers, but how the TET proteins contribute to prevent the onset and maintenance of these malignancies is largely unknown. Here, we highlight recent advances in understanding the physiological function of the TET proteins and their role in regulating DNA methylation and transcription. In addition, we discuss some of the key outstanding questions in the field. |
|---|---|
| AbstractList | Ten eleven translocation (TET) genes, and especially TET2, are frequently mutated in various cancers, but how the TET proteins contribute to the onset and maintenance of these malignancies is largely unknown. In this review, Rasmussen and Helin highlight recent advances in understanding the physiological function of the TET proteins and their role in regulating DNA methylation and transcription.
The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in diseases. The ten eleven translocation (TET) enzymes oxidize 5-methylcytosines (5mCs) and promote locus-specific reversal of DNA methylation.
TET
genes, and especially
TET2
, are frequently mutated in various cancers, but how the TET proteins contribute to prevent the onset and maintenance of these malignancies is largely unknown. Here, we highlight recent advances in understanding the physiological function of the TET proteins and their role in regulating DNA methylation and transcription. In addition, we discuss some of the key outstanding questions in the field. The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in diseases. The ten eleven translocation (TET) enzymes oxidize 5-methylcytosines (5mCs) and promote locus-specific reversal of DNA methylation. TET genes, and especially TET2, are frequently mutated in various cancers, but how the TET proteins contribute to prevent the onset and maintenance of these malignancies is largely unknown. Here, we highlight recent advances in understanding the physiological function of the TET proteins and their role in regulating DNA methylation and transcription. In addition, we discuss some of the key outstanding questions in the field. The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in diseases. The ten eleven translocation (TET) enzymes oxidize 5-methylcytosines (5mCs) and promote locus-specific reversal of DNA methylation. TET genes, and especially TET2, are frequently mutated in various cancers, but how the TET proteins contribute to prevent the onset and maintenance of these malignancies is largely unknown. Here, we highlight recent advances in understanding the physiological function of the TET proteins and their role in regulating DNA methylation and transcription. In addition, we discuss some of the key outstanding questions in the field.The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in diseases. The ten eleven translocation (TET) enzymes oxidize 5-methylcytosines (5mCs) and promote locus-specific reversal of DNA methylation. TET genes, and especially TET2, are frequently mutated in various cancers, but how the TET proteins contribute to prevent the onset and maintenance of these malignancies is largely unknown. Here, we highlight recent advances in understanding the physiological function of the TET proteins and their role in regulating DNA methylation and transcription. In addition, we discuss some of the key outstanding questions in the field. The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in diseases. The ten eleven translocation (TET) enzymes oxidize 5-methylcytosines (5mCs) and promote locus-specific reversal of DNA methylation. TET genes, and especially TET2 , are frequently mutated in various cancers, but how the TET proteins contribute to prevent the onset and maintenance of these malignancies is largely unknown. Here, we highlight recent advances in understanding the physiological function of the TET proteins and their role in regulating DNA methylation and transcription. In addition, we discuss some of the key outstanding questions in the field. |
| Author | Rasmussen, Kasper Dindler Helin, Kristian |
| AuthorAffiliation | 1 Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark 2 Centre for Epigenetics, University of Copenhagen, 2200 Copenhagen, Denmark 4 Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark 3 The Danish Stem Cell Center (Danstem), University of Copenhagen, 2200 Copenhagen, Denmark |
| AuthorAffiliation_xml | – name: 3 The Danish Stem Cell Center (Danstem), University of Copenhagen, 2200 Copenhagen, Denmark – name: 2 Centre for Epigenetics, University of Copenhagen, 2200 Copenhagen, Denmark – name: 4 Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark – name: 1 Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark |
| Author_xml | – sequence: 1 givenname: Kasper Dindler surname: Rasmussen fullname: Rasmussen, Kasper Dindler – sequence: 2 givenname: Kristian orcidid: 0000-0003-1975-6097 surname: Helin fullname: Helin, Kristian |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27036965$$D View this record in MEDLINE/PubMed |
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| Keywords | DNA methylation leukemia DNA demethylation hematopoiesis TET; hydroxymethyl cytosine |
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| Snippet | The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in... Ten eleven translocation (TET) genes, and especially TET2, are frequently mutated in various cancers, but how the TET proteins contribute to the onset and... |
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| SubjectTerms | Animals Cytosine - metabolism Dioxygenases - genetics Dioxygenases - metabolism DNA Methylation - physiology DNA-Binding Proteins - metabolism Epigenesis, Genetic Gene Expression Regulation, Neoplastic Humans Neoplasms - enzymology Neoplasms - genetics Oxidation-Reduction Proto-Oncogene Proteins - metabolism Review |
| Title | Role of TET enzymes in DNA methylation, development, and cancer |
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