Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

• Published in: Cell host & microbe Vol. 19; no. 6; pp. 882 - 890
• Main Authors: Grant, Alesha, Ponia, Sanket S., Tripathi, Shashank, Balasubramaniam, Vinod, Miorin, Lisa, Sourisseau, Marion, Schwarz, Megan C., Sánchez-Seco, Mari Paz, Evans, Matthew J., Best, Sonja M., García-Sastre, Adolfo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.06.2016
• Subjects: Animals; Base Sequence; Calmodulin-Binding Proteins; Calmodulin-Binding Proteins - metabolism; Chlorocebus aethiops; Cytoskeletal Proteins; Cytoskeletal Proteins - metabolism; Disease Models, Animal; HEK293 Cells; HEK293 Cells - drug effects; Humans; Interferon Type I; Interferon Type I - antagonists & inhibitors; Interferon Type I - metabolism; Life Sciences; Mice; Microbiology and Parasitology; Phylogeny; Signal Transduction; STAT2 Transcription Factor; STAT2 Transcription Factor - metabolism; Ubiquitin-Protein Ligases; Ubiquitin-Protein Ligases - metabolism; Vero Cells; Viral Nonstructural Proteins; Viral Nonstructural Proteins - genetics; Viral Nonstructural Proteins - metabolism; Virology; Zika Virus; Zika Virus - metabolism; Zika Virus Infection; Zika Virus Infection - metabolism; Zika Virus Infection - virology

The ongoing epidemic of Zika virus (ZIKV) illustrates the importance of flaviviruses as emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome type I interferon (IFN) to replicate and cause disease in vertebrates. The mechanism(s) by which ZIKV antagonizes IFN sign...