A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence

• Published in: Genes & development Vol. 29; no. 21; pp. 2231 - 2243
• Main Authors: Brien, Gerard L, Healy, Evan, Jerman, Emilia, Conway, Eric, Fadda, Elisa, O'Donovan, Darragh, Krivtsov, Andrei V, Rice, Alan M, Kearney, Conor J, Flaus, Andrew, McDade, Simon S, Martin, Seamus J, McLysaght, Aoife, O'Connell, David J, Armstrong, Scott A, Bracken, Adrian P
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.11.2015
• Subjects: Animals; Cell Proliferation - genetics; Cells, Cultured; Chromatin - metabolism; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; E2F Transcription Factors - metabolism; Gene Expression Regulation, Neoplastic; Humans; Mice; Polycomb-Group Proteins - genetics; Polycomb-Group Proteins - metabolism; Protein Binding; Protein Stability; Protein Structure, Tertiary - genetics; Research Paper; Transcription Factors - metabolism; Tumor Suppressor Protein p53 - metabolism; PHD reader domain; cellular senescence; Polycomb-like; neofunctionalization; cellular quiescence; p53

Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three proteins with such apparent functional redundancy exist in mammals. Here we charact...