Polyploid Giant Cancer Cells Are Frequently Found in the Urine of Prostate Cancer Patients

• Published in: Cancers Vol. 15; no. 13; p. 3366
• Main Authors: Garrido Castillo, Laura Nalleli, Anract, Julien, Delongchamps, Nicolas Barry, Huillard, Olivier, BenMohamed, Fatima, Decina, Alessandra, Lebret, Thierry, Dachez, Roger, Paterlini-Bréchot, Patrizia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.06.2023; MDPI
• Subjects: Biopsy; Cancer; Cancer cells; Care and treatment; Cell size; Cells; Cellular biology; Communication; Development and progression; Diagnosis; Digitization; Giant cells; Medical prognosis; Methylene blue; Morphology; Oncology, Experimental; Patients; Polyploidy; Prostate cancer; Public health; RNA-directed DNA polymerase; Stains & staining; Telomerase reverse transcriptase; Therapeutic targets; Tumorigenesis; Urine; Urology; France; United States > US; Germany; Paris France; polyploid giant cancer cells; PGCC; prostate cancer; giant cells; urine; biomarkers; liquid biopsy
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers15133366

Prostate cancer is the third cause of cancer-related deaths in men. Its early and reliable diagnosis is still a public health issue, generating many useless prostate biopsies. Prostate cancer cells detected in urine could be the target of a powerful test but they are considered too rare. By using an...