The Zinc Finger Transcription Factor Zbtb7b Represses CD8-Lineage Gene Expression in Peripheral CD4 + T Cells
How CD4-CD8 differentiation is maintained in mature T cells is largely unknown. The present study has examined the role in this process of the zinc finger protein Zbtb7b, a critical factor for the commitment of MHC II-restricted thymocytes to the CD4 + lineage. We showed that Zbtb7b acted in periphe...
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Published in | Immunity (Cambridge, Mass.) Vol. 29; no. 6; pp. 876 - 887 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
19.12.2008
Elsevier Limited |
Subjects | |
Online Access | Get full text |
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Summary: | How CD4-CD8 differentiation is maintained in mature T cells is largely unknown. The present study has examined the role in this process of the zinc finger protein Zbtb7b, a critical factor for the commitment of MHC II-restricted thymocytes to the CD4
+ lineage. We showed that Zbtb7b acted in peripheral CD4
+ T cells to suppress CD8-lineage gene expression, including that of CD8 and cytotoxic effector genes perforin and Granzyme B, and was important for the proper repression of interferon-γ (IFN-γ) during effector differentiation. The inappropriate expression of IFN-γ by Zbtb7b-deficient CD4
+ T cells required the activities of Eomesodermin and Runx transcription factors. Runx activity was needed for Granzyme B expression, indicating that Runx proteins control expression of the cytotoxic program. We conclude that a key function of Zbtb7b in the mature CD4
+ T cell compartment is to repress CD8-lineage gene expression. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1074-7613 1097-4180 |
DOI: | 10.1016/j.immuni.2008.09.019 |