Advances and obstacles of T cell-based immunotherapy in gynecological malignancies

• Published in: Molecular cancer Vol. 24; no. 1; pp. 207 - 25
• Main Authors: Zhao, Xi, Ran, Jialing, Li, Shenglong, Chen, Jinxin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.07.2025; BioMed Central; BMC
• Subjects: Animals; Antigens, Neoplasm - immunology; Cancer; CAR-T cell therapy; Cervical cancer; Development and progression; Female; Genital Neoplasms, Female - etiology; Genital Neoplasms, Female - immunology; Genital Neoplasms, Female - therapy; Gynecological malignancies; Health aspects; Humans; Immune response; Immunotherapy; Immunotherapy - methods; Immunotherapy, Adoptive - adverse effects; Immunotherapy, Adoptive - methods; Ovarian cancer; Papillomavirus infections; Receptors, Chimeric Antigen - immunology; Review; Sex discrimination against women; T cell; T cells; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Tumor antigens; Tumor microenvironment; Tumor Microenvironment - immunology; Viral antigens; Gynecological malignancies; Tumor microenvironment; Immunotherapy; T cell; CAR-T cell therapy

T cell-mediated immunotherapy has revolutionized oncology by enabling precision immune responses against malignant cells. Chimeric Antigen Receptor (CAR) T-cell therapy, which involves genetically reprogramming T lymphocytes to recognize tumor-specific antigens, has shown clinical success in hematol...