The Prognostic Relevance of MRI Characteristics in Myxofibrosarcoma Patients Treated with Neoadjuvant Radiotherapy
To improve local control, neoadjuvant radiotherapy (nRT) followed by surgery is the standard of care in myxofibrosarcoma (MFS) because of its infiltrative growth pattern. Nevertheless, local recurrence rates are high. Data on prognostic factors for poor clinical outcomes are lacking. This retrospect...
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| Published in | Cancers Vol. 15; no. 10; p. 2843 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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19.05.2023
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| Abstract | To improve local control, neoadjuvant radiotherapy (nRT) followed by surgery is the standard of care in myxofibrosarcoma (MFS) because of its infiltrative growth pattern. Nevertheless, local recurrence rates are high. Data on prognostic factors for poor clinical outcomes are lacking. This retrospective study thus investigates the prognostic relevance of magnetic resonance imaging (MRI) characteristics before and after nRT in 40 MFS patients, as well as their association with disease-free survival (DFS) and overall survival (OS). A vascular pedicle, defined as extra-tumoral vessels at the tumor periphery, was observed in 12 patients (30.0%) pre-nRT and remained present post-nRT in all cases. Patients with a vascular pedicle had worse DFS (HR 5.85; 95% CI 1.56-21.90;
= 0.009) and OS (HR 9.58; 95% CI 1.91-48.00;
= 0.006). An infiltrative growth pattern, referred to as a tail sign, was observed in 22 patients (55.0%) pre-nRT and in 19 patients (47.5%) post-nRT, and was associated with worse DFS post-nRT (HR 6.99; 95% CI 1.39-35.35;
= 0.019). The percentage of tumor necrosis estimated by MRI was increased post-nRT, but was not associated with survival outcomes. The presence of a tail sign or vascular pedicle on MRI could support the identification of patients at risk for poor clinical outcomes after nRT. |
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| AbstractList | To improve local control, neoadjuvant radiotherapy (nRT) followed by surgery is the standard of care in myxofibrosarcoma (MFS) because of its infiltrative growth pattern. Nevertheless, local recurrence rates are high. Data on prognostic factors for poor clinical outcomes are lacking. This retrospective study thus investigates the prognostic relevance of magnetic resonance imaging (MRI) characteristics before and after nRT in 40 MFS patients, as well as their association with disease-free survival (DFS) and overall survival (OS). A vascular pedicle, defined as extra-tumoral vessels at the tumor periphery, was observed in 12 patients (30.0%) pre-nRT and remained present post-nRT in all cases. Patients with a vascular pedicle had worse DFS (HR 5.85; 95% CI 1.56-21.90;
= 0.009) and OS (HR 9.58; 95% CI 1.91-48.00;
= 0.006). An infiltrative growth pattern, referred to as a tail sign, was observed in 22 patients (55.0%) pre-nRT and in 19 patients (47.5%) post-nRT, and was associated with worse DFS post-nRT (HR 6.99; 95% CI 1.39-35.35;
= 0.019). The percentage of tumor necrosis estimated by MRI was increased post-nRT, but was not associated with survival outcomes. The presence of a tail sign or vascular pedicle on MRI could support the identification of patients at risk for poor clinical outcomes after nRT. Myxofibrosarcomas (MFS) are malignant soft tissue tumors, frequently located in the extremities. Owing to the infiltrative growth pattern of MFS, neoadjuvant radiotherapy (nRT) is commonly used before surgery to improve local control. Nevertheless, high local recurrence rates are typical in MFS. Data on prognostic factors for poor clinical outcomes are lacking. This retrospective study investigates the prognostic relevance of magnetic resonance imaging (MRI) characteristics before and after nRT in 40 MFS patients. The presence of a vascular pedicle, defined as extra-tumoral vessels at the tumor periphery, was prognostic for both worse disease-free survival (DFS) and overall survival. Additionally, the presence of an infiltrative pattern, referred to as a tail sign, was prognostic for worse DFS. These MRI characteristics could support the identification of patients at risk for poor clinical outcomes after nRT. Simple SummaryMyxofibrosarcomas (MFS) are malignant soft tissue tumors, frequently located in the extremities. Owing to the infiltrative growth pattern of MFS, neoadjuvant radiotherapy (nRT) is commonly used before surgery to improve local control. Nevertheless, high local recurrence rates are typical in MFS. Data on prognostic factors for poor clinical outcomes are lacking. This retrospective study investigates the prognostic relevance of magnetic resonance imaging (MRI) characteristics before and after nRT in 40 MFS patients. The presence of a vascular pedicle, defined as extra-tumoral vessels at the tumor periphery, was prognostic for both worse disease-free survival (DFS) and overall survival. Additionally, the presence of an infiltrative pattern, referred to as a tail sign, was prognostic for worse DFS. These MRI characteristics could support the identification of patients at risk for poor clinical outcomes after nRT.AbstractTo improve local control, neoadjuvant radiotherapy (nRT) followed by surgery is the standard of care in myxofibrosarcoma (MFS) because of its infiltrative growth pattern. Nevertheless, local recurrence rates are high. Data on prognostic factors for poor clinical outcomes are lacking. This retrospective study thus investigates the prognostic relevance of magnetic resonance imaging (MRI) characteristics before and after nRT in 40 MFS patients, as well as their association with disease-free survival (DFS) and overall survival (OS). A vascular pedicle, defined as extra-tumoral vessels at the tumor periphery, was observed in 12 patients (30.0%) pre-nRT and remained present post-nRT in all cases. Patients with a vascular pedicle had worse DFS (HR 5.85; 95% CI 1.56–21.90; p = 0.009) and OS (HR 9.58; 95% CI 1.91–48.00; p = 0.006). An infiltrative growth pattern, referred to as a tail sign, was observed in 22 patients (55.0%) pre-nRT and in 19 patients (47.5%) post-nRT, and was associated with worse DFS post-nRT (HR 6.99; 95% CI 1.39–35.35; p = 0.019). The percentage of tumor necrosis estimated by MRI was increased post-nRT, but was not associated with survival outcomes. The presence of a tail sign or vascular pedicle on MRI could support the identification of patients at risk for poor clinical outcomes after nRT. Myxofibrosarcomas (MFS) are malignant soft tissue tumors, frequently located in the extremities. Owing to the infiltrative growth pattern of MFS, neoadjuvant radiotherapy (nRT) is commonly used before surgery to improve local control. Nevertheless, high local recurrence rates are typical in MFS. Data on prognostic factors for poor clinical outcomes are lacking. This retrospective study investigates the prognostic relevance of magnetic resonance imaging (MRI) characteristics before and after nRT in 40 MFS patients. The presence of a vascular pedicle, defined as extra-tumoral vessels at the tumor periphery, was prognostic for both worse disease-free survival (DFS) and overall survival. Additionally, the presence of an infiltrative pattern, referred to as a tail sign, was prognostic for worse DFS. These MRI characteristics could support the identification of patients at risk for poor clinical outcomes after nRT. To improve local control, neoadjuvant radiotherapy (nRT) followed by surgery is the standard of care in myxofibrosarcoma (MFS) because of its infiltrative growth pattern. Nevertheless, local recurrence rates are high. Data on prognostic factors for poor clinical outcomes are lacking. This retrospective study thus investigates the prognostic relevance of magnetic resonance imaging (MRI) characteristics before and after nRT in 40 MFS patients, as well as their association with disease-free survival (DFS) and overall survival (OS). A vascular pedicle, defined as extra-tumoral vessels at the tumor periphery, was observed in 12 patients (30.0%) pre-nRT and remained present post-nRT in all cases. Patients with a vascular pedicle had worse DFS (HR 5.85; 95% CI 1.56-21.90; p = 0.009) and OS (HR 9.58; 95% CI 1.91-48.00; p = 0.006). An infiltrative growth pattern, referred to as a tail sign, was observed in 22 patients (55.0%) pre-nRT and in 19 patients (47.5%) post-nRT, and was associated with worse DFS post-nRT (HR 6.99; 95% CI 1.39-35.35; p = 0.019). The percentage of tumor necrosis estimated by MRI was increased post-nRT, but was not associated with survival outcomes. The presence of a tail sign or vascular pedicle on MRI could support the identification of patients at risk for poor clinical outcomes after nRT. To improve local control, neoadjuvant radiotherapy (nRT) followed by surgery is the standard of care in myxofibrosarcoma (MFS) because of its infiltrative growth pattern. Nevertheless, local recurrence rates are high. Data on prognostic factors for poor clinical outcomes are lacking. This retrospective study thus investigates the prognostic relevance of magnetic resonance imaging (MRI) characteristics before and after nRT in 40 MFS patients, as well as their association with disease-free survival (DFS) and overall survival (OS). A vascular pedicle, defined as extra-tumoral vessels at the tumor periphery, was observed in 12 patients (30.0%) pre-nRT and remained present post-nRT in all cases. Patients with a vascular pedicle had worse DFS (HR 5.85; 95% CI 1.56–21.90; p = 0.009) and OS (HR 9.58; 95% CI 1.91–48.00; p = 0.006). An infiltrative growth pattern, referred to as a tail sign, was observed in 22 patients (55.0%) pre-nRT and in 19 patients (47.5%) post-nRT, and was associated with worse DFS post-nRT (HR 6.99; 95% CI 1.39–35.35; p = 0.019). The percentage of tumor necrosis estimated by MRI was increased post-nRT, but was not associated with survival outcomes. The presence of a tail sign or vascular pedicle on MRI could support the identification of patients at risk for poor clinical outcomes after nRT. |
| Audience | Academic |
| Author | Schreuder, Bart H W van Herpen, Carla M L Flucke, Uta E Nederkoorn, Maikel J L de Rooy, Jacky W J Bonenkamp, Johannes J de Wilt, Johannes H W van Ravensteijn, Stefan G Desar, Ingrid M E Versleijen-Jonkers, Yvonne M H Braam, Pètra M Wal, Tom C P |
| AuthorAffiliation | 2 Department of Radiotherapy, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands; p.braam@radboudumc.nl 5 Department of Orthopedics, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands; bart.schreuder@radboudumc.nl 4 Department of Surgery, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands; han.bonenkamp@radboudumc.nl (J.J.B.); hans.dewilt@radboudumc.nl (J.H.W.d.W.) 6 Department of Radiology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands; jacky.derooy@radboudumc.nl 1 Department of Medical Oncology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands; stefan.ravensteijn@radboudumc.nl (S.G.v.R.); maikel.nederkoorn@radboudumc.nl (M.J.L.N.); tom.wal@radboudumc.nl (T.C.P.W.); yvonne.versleijen-jonkers@radboudumc.nl (Y.M.H.V.-J.); carla.vanherpen@radboudumc.nl (C.M.L.v.H.) 3 Department of Pathology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands; uta.flucke@radboudumc.nl |
| AuthorAffiliation_xml | – name: 1 Department of Medical Oncology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands; stefan.ravensteijn@radboudumc.nl (S.G.v.R.); maikel.nederkoorn@radboudumc.nl (M.J.L.N.); tom.wal@radboudumc.nl (T.C.P.W.); yvonne.versleijen-jonkers@radboudumc.nl (Y.M.H.V.-J.); carla.vanherpen@radboudumc.nl (C.M.L.v.H.) – name: 5 Department of Orthopedics, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands; bart.schreuder@radboudumc.nl – name: 2 Department of Radiotherapy, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands; p.braam@radboudumc.nl – name: 4 Department of Surgery, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands; han.bonenkamp@radboudumc.nl (J.J.B.); hans.dewilt@radboudumc.nl (J.H.W.d.W.) – name: 6 Department of Radiology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands; jacky.derooy@radboudumc.nl – name: 3 Department of Pathology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands; uta.flucke@radboudumc.nl |
| Author_xml | – sequence: 1 givenname: Stefan G orcidid: 0000-0003-4069-3932 surname: van Ravensteijn fullname: van Ravensteijn, Stefan G organization: Department of Medical Oncology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands – sequence: 2 givenname: Maikel J L surname: Nederkoorn fullname: Nederkoorn, Maikel J L organization: Department of Medical Oncology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands – sequence: 3 givenname: Tom C P orcidid: 0009-0003-8951-6256 surname: Wal fullname: Wal, Tom C P organization: Department of Medical Oncology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands – sequence: 4 givenname: Yvonne M H orcidid: 0000-0001-7623-0505 surname: Versleijen-Jonkers fullname: Versleijen-Jonkers, Yvonne M H organization: Department of Medical Oncology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands – sequence: 5 givenname: Pètra M surname: Braam fullname: Braam, Pètra M organization: Department of Radiotherapy, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands – sequence: 6 givenname: Uta E surname: Flucke fullname: Flucke, Uta E organization: Department of Pathology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands – sequence: 7 givenname: Johannes J surname: Bonenkamp fullname: Bonenkamp, Johannes J organization: Department of Surgery, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands – sequence: 8 givenname: Bart H W surname: Schreuder fullname: Schreuder, Bart H W organization: Department of Orthopedics, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands – sequence: 9 givenname: Carla M L surname: van Herpen fullname: van Herpen, Carla M L organization: Department of Medical Oncology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands – sequence: 10 givenname: Johannes H W surname: de Wilt fullname: de Wilt, Johannes H W organization: Department of Surgery, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands – sequence: 11 givenname: Ingrid M E surname: Desar fullname: Desar, Ingrid M E organization: Department of Medical Oncology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands – sequence: 12 givenname: Jacky W J surname: de Rooy fullname: de Rooy, Jacky W J organization: Department of Radiology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands |
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| Cites_doi | 10.1016/j.humpath.2013.07.045 10.1002/jso.25522 10.3322/caac.21388 10.20944/preprints202107.0133.v1 10.1007/s00256-021-03894-6 10.1016/j.ejrad.2019.06.007 10.1177/17588359221093973 10.1016/j.ejso.2016.05.015 10.3390/cancers12082258 10.3389/fonc.2019.00280 10.1016/j.acra.2020.08.018 10.1016/j.ctrv.2018.05.007 10.1148/radiol.2015142463 10.1245/s10434-012-2572-3 10.1111/ajco.13161 10.1016/j.humpath.2004.01.016 10.1016/j.ejso.2021.02.024 10.1097/COC.0000000000000692 10.1007/s00432-019-02885-4 10.1080/0284186X.2023.2166427 10.1186/s12885-020-6683-0 10.1097/COC.0000000000000382 10.21873/anticanres.13430 10.3390/cancers14051102 10.1002/cncr.34506 10.1002/jso.23708 10.1016/j.ejca.2015.12.008 10.1245/s10434-010-1341-4 10.1007/s00256-014-1992-5 10.1007/s00256-012-1563-6 10.1097/CORR.0000000000001287 10.1155/2019/8517371 10.1302/0301-620X.102B6.BJJ-2019-1307.R1 10.1097/00000658-200203000-00015 10.1016/S1470-2045(12)70346-7 10.1245/s10434-017-6019-8 10.1016/j.ejca.2015.09.021 10.1016/j.ejso.2016.02.004 10.1007/s00330-014-3181-2 |
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| Copyright | COPYRIGHT 2023 MDPI AG 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023 by the authors. 2023 |
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| Keywords | magnetic resonance imaging vascular pedicle myxofibrosarcoma neoadjuvant radiotherapy local recurrence prognostic factors tail sign soft tissue sarcoma |
| Language | English |
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| References | Kikuta (ref_24) 2015; 44 Albergo (ref_19) 2023; 129 Lenze (ref_8) 2019; 39 Suda (ref_34) 2020; 102-B Ledoux (ref_26) 2019; 117 Amin (ref_28) 2017; 67 Sambri (ref_13) 2016; 42 ref_32 Stojadinovic (ref_10) 2002; 235 Collier (ref_37) 2020; 43 Sanfilippo (ref_9) 2011; 18 Hornicek (ref_4) 2013; 20 Collier (ref_36) 2021; 479 Sambri (ref_6) 2019; 15 ref_15 Messiou (ref_35) 2016; 56 Woll (ref_40) 2012; 13 Lefkowitz (ref_27) 2013; 42 Soldatos (ref_38) 2016; 278 Swami (ref_25) 2022; 51 Reijers (ref_22) 2023; 62 Spinnato (ref_5) 2021; 28 Beltrami (ref_14) 2016; 42 Huang (ref_11) 2004; 35 Gannon (ref_18) 2019; 145 Teurneau (ref_12) 2019; 2019 Imanishi (ref_31) 2016; 36 Salah (ref_20) 2018; 69 Gannon (ref_17) 2019; 120 Setsu (ref_29) 2014; 45 ref_3 ref_2 Wardelmann (ref_33) 2016; 53 Odei (ref_7) 2018; 41 Winfield (ref_39) 2019; 9 Iwata (ref_30) 2014; 110 Bonvalot (ref_21) 2021; 47 Vanni (ref_1) 2022; 14 Gingrich (ref_16) 2017; 24 Yoo (ref_23) 2014; 24 |
| References_xml | – volume: 45 start-page: 137 year: 2014 ident: ref_29 article-title: Histological analysis suggests an invasion-independent metastatic mechanism in alveolar soft part sarcoma publication-title: Hum. Pathol. doi: 10.1016/j.humpath.2013.07.045 contributor: fullname: Setsu – volume: 120 start-page: 325 year: 2019 ident: ref_17 article-title: The role of radiation therapy and margin width in localized soft-tissue sarcoma: Analysis from the US Sarcoma Collaborative publication-title: J. Surg. Oncol. doi: 10.1002/jso.25522 contributor: fullname: Gannon – volume: 67 start-page: 93 year: 2017 ident: ref_28 article-title: The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21388 contributor: fullname: Amin – ident: ref_32 doi: 10.20944/preprints202107.0133.v1 – volume: 51 start-page: 807 year: 2022 ident: ref_25 article-title: Soft tissue solitary fibrous tumors of the musculoskeletal system: Spectrum of MRI appearances and characteristic imaging features publication-title: Skeletal Radiol. doi: 10.1007/s00256-021-03894-6 contributor: fullname: Swami – volume: 117 start-page: 112 year: 2019 ident: ref_26 article-title: Abnormal vascularization of soft-tissue sarcomas on conventional MRI: Diagnostic and prognostic values publication-title: Eur. J. Radiol. doi: 10.1016/j.ejrad.2019.06.007 contributor: fullname: Ledoux – volume: 14 start-page: 17588359221093973 year: 2022 ident: ref_1 article-title: Myxofibrosarcoma landscape: Diagnostic pitfalls, clinical management and future perspectives publication-title: Ther. Adv. Med. Oncol. doi: 10.1177/17588359221093973 contributor: fullname: Vanni – volume: 42 start-page: 1042 year: 2016 ident: ref_13 article-title: Surgical Margins Do Not Affect Prognosis in High Grade Myxofibrosarcoma publication-title: Eur. J. Surg. Oncol. doi: 10.1016/j.ejso.2016.05.015 contributor: fullname: Sambri – ident: ref_15 doi: 10.3390/cancers12082258 – volume: 9 start-page: 280 year: 2019 ident: ref_39 article-title: Utility of Multi-Parametric Quantitative Magnetic Resonance Imaging for Characterization and Radiotherapy Response Assessment in Soft-Tissue Sarcomas and Correlation With Histopathology publication-title: Front. Oncol. doi: 10.3389/fonc.2019.00280 contributor: fullname: Winfield – volume: 28 start-page: 1524 year: 2021 ident: ref_5 article-title: MRI Features as Prognostic Factors in Myxofibrosarcoma: Proposal of MRI Grading System publication-title: Acad. Radiol. doi: 10.1016/j.acra.2020.08.018 contributor: fullname: Spinnato – volume: 69 start-page: 1 year: 2018 ident: ref_20 article-title: Tumor necrosis and clinical outcomes following neoadjuvant therapy in soft tissue sarcoma: A systematic review and meta-analysis publication-title: Cancer Treat. Rev. doi: 10.1016/j.ctrv.2018.05.007 contributor: fullname: Salah – volume: 278 start-page: 831 year: 2016 ident: ref_38 article-title: Multiparametric Assessment of Treatment Response in High-Grade Soft-Tissue Sarcomas with Anatomic and Functional MR Imaging Sequences publication-title: Radiology doi: 10.1148/radiol.2015142463 contributor: fullname: Soldatos – volume: 20 start-page: 80 year: 2013 ident: ref_4 article-title: Prognostic factors and outcomes of patients with myxofibrosarcoma publication-title: Ann. Surg. Oncol. doi: 10.1245/s10434-012-2572-3 contributor: fullname: Hornicek – volume: 15 start-page: e181 year: 2019 ident: ref_6 article-title: Does pre-operative MRI predict the risk of local recurrence in primary myxofibrosarcoma of the extremities? publication-title: Asia Pac. J. Clin. Oncol. doi: 10.1111/ajco.13161 contributor: fullname: Sambri – volume: 35 start-page: 612 year: 2004 ident: ref_11 article-title: Low-Grade Myxofibrosarcoma: A Clinicopathologic Analysis of 49 Cases Treated at a Single Institution with Simultaneous Assessment of the Efficacy of 3-Tier and 4-Tier Grading Systems publication-title: Hum. Pathol. doi: 10.1016/j.humpath.2004.01.016 contributor: fullname: Huang – volume: 47 start-page: 2166 year: 2021 ident: ref_21 article-title: Complete pathological response to neoadjuvant treatment is associated with better survival outcomes in patients with soft tissue sarcoma: Results of a retrospective multicenter study publication-title: Eur. J. Surg. Oncol. doi: 10.1016/j.ejso.2021.02.024 contributor: fullname: Bonvalot – volume: 43 start-page: 491 year: 2020 ident: ref_37 article-title: Six-Week Interval Between Preoperative Radiation and Surgery Is Associated With Fewer Major Wound Complications in Soft Tissue Sarcoma publication-title: Am. J. Clin. Oncol. doi: 10.1097/COC.0000000000000692 contributor: fullname: Collier – volume: 36 start-page: 2339 year: 2016 ident: ref_31 article-title: Tail of Superficial Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma After Preoperative Radiotherapy publication-title: Anticancer Res. contributor: fullname: Imanishi – volume: 145 start-page: 1321 year: 2019 ident: ref_18 article-title: Pathologic necrosis following neoadjuvant radiotherapy or chemoradiotherapy is prognostic of poor survival in soft tissue sarcoma publication-title: J. Cancer Res. Clin. Oncol. doi: 10.1007/s00432-019-02885-4 contributor: fullname: Gannon – volume: 62 start-page: 25 year: 2023 ident: ref_22 article-title: Correlation of radiological and histopathological response after neoadjuvant radiotherapy in soft tissue sarcoma publication-title: Acta Oncol. doi: 10.1080/0284186X.2023.2166427 contributor: fullname: Reijers – ident: ref_2 doi: 10.1186/s12885-020-6683-0 – volume: 41 start-page: 827 year: 2018 ident: ref_7 article-title: Predictors of Local Recurrence in Patients with Myxofibrosarcoma publication-title: Am. J. Clin. Oncol. doi: 10.1097/COC.0000000000000382 contributor: fullname: Odei – volume: 39 start-page: 2985 year: 2019 ident: ref_8 article-title: Prognostic Factors and Outcomes for Patients with Myxofibrosarcoma: A 13-Year Retrospective Evaluation publication-title: Anticancer Res. doi: 10.21873/anticanres.13430 contributor: fullname: Lenze – ident: ref_3 doi: 10.3390/cancers14051102 – volume: 129 start-page: 60 year: 2023 ident: ref_19 article-title: Complete tumor necrosis after neoadjuvant chemotherapy defines good responders in patients with Ewing sarcoma publication-title: Cancer doi: 10.1002/cncr.34506 contributor: fullname: Albergo – volume: 110 start-page: 707 year: 2014 ident: ref_30 article-title: Impact of infiltrative growth on the outcome of patients with undifferentiated pleomorphic sarcoma and myxofibrosarcoma publication-title: J. Surg. Oncol. doi: 10.1002/jso.23708 contributor: fullname: Iwata – volume: 56 start-page: 37 year: 2016 ident: ref_35 article-title: Evaluation of response after pre-operative radiotherapy in soft tissue sarcomas; the European Organisation for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) and Imaging Group recommendations for radiological examination and reporting with an emphasis on magnetic resonance imaging publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2015.12.008 contributor: fullname: Messiou – volume: 18 start-page: 720 year: 2011 ident: ref_9 article-title: Myxofibrosarcoma: Prognostic Factors and Survival in a Series of Patients Treated at a Single Institution publication-title: Ann. Surg. Oncol. doi: 10.1245/s10434-010-1341-4 contributor: fullname: Sanfilippo – volume: 44 start-page: 55 year: 2015 ident: ref_24 article-title: An analysis of factors related to the tail-like pattern of myxofibrosarcoma seen on MRI publication-title: Skeletal Radiol. doi: 10.1007/s00256-014-1992-5 contributor: fullname: Kikuta – volume: 42 start-page: 809 year: 2013 ident: ref_27 article-title: Myxofibrosarcoma: Prevalence and diagnostic value of the "tail sign" on magnetic resonance imaging publication-title: Skeletal Radiol. doi: 10.1007/s00256-012-1563-6 contributor: fullname: Lefkowitz – volume: 479 start-page: 506 year: 2021 ident: ref_36 article-title: The Interval Between Preoperative Radiation and Surgery Is Not Associated with Overall Survival for Soft-tissue Sarcomas: An Analysis of the National Cancer Database publication-title: Clin. Orthop. Relat. Res. doi: 10.1097/CORR.0000000000001287 contributor: fullname: Collier – volume: 2019 start-page: 8517371 year: 2019 ident: ref_12 article-title: High Recurrence Rate of Myxofibrosarcoma: The Effect of Radiotherapy Is Not Clear publication-title: Sarcoma doi: 10.1155/2019/8517371 contributor: fullname: Teurneau – volume: 102-B start-page: 795 year: 2020 ident: ref_34 article-title: Impact of chemotherapy-induced necrosis on event-free and overall survival after preoperative MAP chemotherapy in patients with primary high-grade localized osteosarcoma publication-title: Bone Joint J. doi: 10.1302/0301-620X.102B6.BJJ-2019-1307.R1 contributor: fullname: Suda – volume: 235 start-page: 424 year: 2002 ident: ref_10 article-title: Analysis of the Prognostic Significance of Microscopic Margins in 2,084 Localized Primary Adult Soft Tissue Sarcomas publication-title: Ann. Surg. doi: 10.1097/00000658-200203000-00015 contributor: fullname: Stojadinovic – volume: 13 start-page: 1045 year: 2012 ident: ref_40 article-title: EORTC Soft Tissue and Bone Sarcoma Group and the NCIC Clinical Trials Group Sarcoma Disease Site Committee. Adjuvant chemotherapy with doxorubicin, ifosfamide, and lenograstim for resected soft-tissue sarcoma (EORTC 62931): A multicentre randomised controlled trial publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(12)70346-7 contributor: fullname: Woll – volume: 24 start-page: 3252 year: 2017 ident: ref_16 article-title: Neoadjuvant Radiotherapy Is Associated with R0 Resection and Improved Survival for Patients with Extremity Soft Tissue Sarcoma Undergoing Surgery: A National Cancer Database Analysis publication-title: Ann. Surg. Oncol. doi: 10.1245/s10434-017-6019-8 contributor: fullname: Gingrich – volume: 53 start-page: 84 year: 2016 ident: ref_33 article-title: Evaluation of response after neoadjuvant treatment in soft tissue sarcomas; the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) recommendations for pathological examination and reporting publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2015.09.021 contributor: fullname: Wardelmann – volume: 42 start-page: 1057 year: 2016 ident: ref_14 article-title: Combining limb-sparing surgery with radiation therapy in high-grade soft tissue sarcoma of extremities—Is it effective? publication-title: Eur. J. Surg. Oncol. doi: 10.1016/j.ejso.2016.02.004 contributor: fullname: Beltrami – volume: 24 start-page: 1749 year: 2014 ident: ref_23 article-title: MR imaging of myxofibrosarcoma and undifferentiated sarcoma with emphasis on tail sign; diagnostic and prognostic value publication-title: Eur. Radiol. doi: 10.1007/s00330-014-3181-2 contributor: fullname: Yoo |
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| Snippet | To improve local control, neoadjuvant radiotherapy (nRT) followed by surgery is the standard of care in myxofibrosarcoma (MFS) because of its infiltrative... Myxofibrosarcomas (MFS) are malignant soft tissue tumors, frequently located in the extremities. Owing to the infiltrative growth pattern of MFS, neoadjuvant... Simple SummaryMyxofibrosarcomas (MFS) are malignant soft tissue tumors, frequently located in the extremities. Owing to the infiltrative growth pattern of MFS,... |
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| SubjectTerms | Edema Growth patterns Magnetic resonance imaging Medical prognosis Metastasis Patients Radiation therapy Radiotherapy Sarcoma Surgery Survival Tails Tumors |
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| Title | The Prognostic Relevance of MRI Characteristics in Myxofibrosarcoma Patients Treated with Neoadjuvant Radiotherapy |
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