Impaired endothelial function and increased carotid stiffness in 9-year-old children with low birthweight

• Published in: Circulation (New York, N.Y.) Vol. 102; no. 22; pp. 2739 - 2744
• Main Authors: MARTIN, Helena, JIE HU, GENNSER, Gerhard, NORMAN, Mikael
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 28.11.2000; American Heart Association, Inc
• Subjects: Acetylcholine - pharmacology; Adult; Age Factors; Biological and medical sciences; Blood Pressure - physiology; Body Mass Index; Carotid Arteries - pathology; Carotid Arteries - physiopathology; Child; Delivery. Postpartum. Lactation; Disorders; Elasticity; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Female; Gynecology. Andrology. Obstetrics; Heart Rate - physiology; Humans; Infant, Low Birth Weight; Infant, Newborn; Male; Maternal Age; Medical sciences; Medicin och hälsovetenskap; Nitroglycerin - pharmacology; Sex Factors; Vasodilation - drug effects; Human; Pregnancy disorders; Pathophysiology; Low birth weight; Cardiovascular disease; Exploration; Endothelium; Newborn diseases; Prematurity; Carotid; Risk factor; Stiffness; Vascular wall; Child

Low birthweight (LBW) has been associated with an increased incidence of adult cardiovascular disease. Endothelial dysfunction and loss of arterial elasticity are early markers of hypertension and atherosclerosis. We studied the prevalence of these markers in 44 healthy, prepubertal (age 9+/-1.3 yea...