A randomized, double‐blind, crossover comparison among cetirizine, levocetirizine, and ucb 28557 on histamine‐induced cutaneous responses in healthy adult volunteers

• Published in: Allergy (Copenhagen) Vol. 56; no. 1; pp. 50 - 57
• Main Authors: Devalia, J. L., Hanotte, F., Baltes, E., De Vos, C.
• Format: Journal Article
• Language: English
• Published: Copenhagen Munksgaard International Publishers 01.01.2001; Blackwell
• Subjects: Adolescent; Adult; Anti-Allergic Agents - adverse effects; Anti-Allergic Agents - pharmacokinetics; Anti-Allergic Agents - pharmacology; antihistamines; Biological and medical sciences; cetirizine; Cetirizine - adverse effects; Cetirizine - pharmacokinetics; Cetirizine - pharmacology; Cross-Over Studies; Double-Blind Method; equivalence; histamine; Histamine - pharmacology; Histamine and antagonists. Allergy; Histamine H1 Antagonists - adverse effects; Histamine H1 Antagonists - pharmacokinetics; Histamine H1 Antagonists - pharmacology; Humans; levocetirizine; Male; Medical sciences; Pharmacology. Drug treatments; Skin Tests; Stereoisomerism; ucb 28557; urinary excretion; urticaria; Human; Immunopathology; Skin disease; Urticaria; Antiasthma agent; Cetirizine; Antihistaminic; Biological activity; Chemotherapy; Randomization; Treatment; Enantiomer; Double blind study; Antagonist; H1 Histamine receptor; Levocetirizine; Comparative study

Background: Cetirizine is a highly efficacious and long‐acting second‐generation H1‐receptor antagonist for the treatment of allergic diseases, such as allergic rhinitis and chronic idiopathic urticaria, in adults and children. Pharmacologic studies have demonstrated that cetirizine, a racemate mixt...