Histological characteristics of 21 Papua New Guinean children with high-grade B-cell lymphoma, which is frequently associated with EBV infection

• Published in: Pathology international Vol. 58; no. 11; pp. 695 - 700
• Main Authors: Nomura, Yuko, Lavu, Evelyn Koru, Muta, Koichiro, Niino, Daisuke, Takeshita, Morishige, Hirose, Shinichi, Nakamura, Shigeo, Yoshino, Tadashi, Kikuchi, Masahiro, Ohshima, Koichi
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.11.2008
• Subjects: Adolescent; Antigens, Viral - analysis; Biomarkers, Tumor - analysis; Burkitt lymphoma; Burkitt Lymphoma - pathology; Burkitt Lymphoma - virology; Child; Child, Preschool; EBV; Epstein-Barr virus; Epstein-Barr Virus Infections - pathology; Epstein-Barr Virus Infections - virology; Epstein-Barr Virus Nuclear Antigens - analysis; Female; Herpesvirus 4, Human - genetics; Herpesvirus 4, Human - immunology; Herpesvirus 4, Human - isolation & purification; high-grade lymphoma; Humans; Immunophenotyping; In Situ Hybridization; Lymphoma, B-Cell - pathology; Lymphoma, B-Cell - virology; Male; New Guinea; Papua New Guinea; RNA, Viral - analysis; Viral Proteins - analysis; New Guinea

The aim of the present study was to confirm the histopathological features of aggressive B‐cell lymphoma in Papua New Guinea (PNG)—an EBV endemic region. The immunophenotypic features and expression of EBV‐encoded proteins and RNA in B‐cell lymphomas were analyzed in 21 PNG children, and compared to...