Cerebral blood flow, oxidative metabolism and cerebrovascular carbon dioxide reactivity in patients with acute bacterial meningitis

• Published in: Acta anaesthesiologica Scandinavica Vol. 46; no. 5; pp. 567 - 578
• Main Authors: Møller, K., Strauss, G. I., Thomsen, G., Larsen, F. S., Holm, S., Sperling, B. K., Skinhøj, P., Knudsen, G. M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Munksgaard International Publishers 01.05.2002; Blackwell
• Subjects: Adult; Aged; Aged, 80 and over; Algorithms; Bacterial diseases; Bacterial diseases of the nervous system. Bacterial myositis; Bacterial meningitis; Biological and medical sciences; Blood Glucose - metabolism; brain; Brain Chemistry - physiology; Carbon Dioxide - blood; Cerebrovascular Circulation - physiology; emission-computed; Female; Human bacterial diseases; Humans; hyperventilation; Infectious diseases; Lactic Acid - blood; Male; Medical sciences; Meningitis, Bacterial - blood; Meningitis, Bacterial - physiopathology; metabolism; Middle Aged; Oxidation-Reduction; Oxygen - blood; Oxygen Consumption - physiology; Prospective Studies; regional blood flow; single-photon; tomography; Tomography, Emission-Computed, Single-Photon; Nervous system diseases; Oxygen; Acute; Carbon dioxide; Glucose; Metabolism; Blood flow; Infection; Lactates; Reactivity; Central nervous system disease; Bacteriosis; Meningitis; Hemodynamics; Hyperventilation

Background: The optimal arterial carbon dioxide tension (PaCO2) in patients with acute bacterial meningitis (ABM) is unknown and controversial. The objective of this study was to measure global cerebral blood flow (CBF), cerebrovascular CO2 reactivity (CO2R), and cerebral metabolic rates (CMR) of ox...