Analysis of the HLA and non-HLA susceptibility loci in Japanese type 1 diabetes

• Published in: Diabetes/metabolism research and reviews Vol. 27; no. 8; pp. 844 - 848
• Main Authors: Yamashita, Hisakuni, Awata, Takuya, Kawasaki, Eiji, Ikegami, Hiroshi, Tanaka, Shoichiro, Maruyama, Taro, Shimada, Akira, Nakanishi, Koji, Takahashi, Kazuma, Kobayashi, Tetsuro, Kawabata, Yumiko, Miyashita, Yumi, Kurihara, Susumu, Morita-Ohkubo, Tomoko, Katayama, Shigehiro
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.11.2011; Wiley Subscription Services, Inc
• Subjects: Age of Onset; Asian Continental Ancestry Group - genetics; Autoantibodies - analysis; Autoimmunity; CTLA-4 protein; Diabetes mellitus; Diabetes Mellitus, Type 1 - genetics; Drb1 protein; ErbB-3 protein; Female; Genetic Predisposition to Disease - genetics; genetic susceptibility; Haplotypes; Histocompatibility antigen HLA; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class II - genetics; HLA-DR Antigens - genetics; HLA-DRB1 Chains - genetics; Humans; Insulin - genetics; Interleukin 2 receptors; Interleukin 7 receptors; Interleukin-2 Receptor alpha Subunit - genetics; Lectins, C-Type - genetics; Male; Monosaccharide Transport Proteins - genetics; Polymorphism, Single Nucleotide; prediction model; Reviews; Single-nucleotide polymorphism; Thyroid; Thyroid Gland - immunology; Tissue typing; type 1 diabetes

Background We previously reported the associations of human leukocyte antigen (HLA) (DRB1 and DQB1), INS, CTLA4, IL2RA, ERBB3 and CLEC16A with Japanese type 1 diabetes (T1D). In this study, we jointly analysed these loci in addition to IFIH1 and IL7R. Methods A maximum of 790 T1D patients and 953 co...