Insulin Enhances Endothelial Function Throughout the Arterial Tree in Healthy But Not Metabolic Syndrome Subjects

• Published in: The journal of clinical endocrinology and metabolism Vol. 101; no. 3; pp. 1198 - 1206
• Main Authors: Jahn, Linda A., Hartline, Lee, Rao, Nagashree, Logan, Brent, Kim, Justin J., Aylor, Kevin, Gan, Li-Ming, Westergren, Helena U., Barrett, Eugene J.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.03.2016; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adult; Arteries; Arteries - drug effects; Arteries - physiopathology; Arterioles; Biomarkers; Blood Flow Velocity - drug effects; Cardiovascular disease; Cardiovascular diseases; cardiovascular events; Clinical Medicine; dependent vasodilation; diabetes-mellitus; Disease resistance; dysfunction; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Female; Flow velocity; Glucose Clamp Technique; glucose-uptake; Health; Humans; Hyperinsulinemia; Insulin - pharmacology; Insulin resistance; Klinisk medicin; Male; Metabolic syndrome; Metabolic Syndrome - physiopathology; microvascular; Microvasculature; Middle Aged; nitric-oxide; Original; oxidative; Pulse Wave Analysis; recruitment; skeletal-muscle; stress; Vascular Resistance - drug effects; Vascular Resistance - physiology; Veins & arteries; Velocity
• ISSN: 0021-972X; 1945-7197; 1945-7197
• DOI: 10.1210/jc.2015-3293

Context:Insulin reportedly impairs endothelial function in conduit arteries but improves it in resistance and microvascular arterioles in healthy humans. No studies have assessed endothelial function at three arterial levels in healthy or metabolic syndrome (METSYN) subjects.Objective:The objective...