Bone Morphogenetic Protein 7 (BMP7) Gene Polymorphisms Are Associated With Inverse Relationships Between Vascular Calcification and BMD: The Diabetes Heart Study

• Published in: Journal of bone and mineral research Vol. 24; no. 10; pp. 1719 - 1727
• Main Authors: Freedman, Barry I, Bowden, Donald W, Ziegler, Julie T, Langefeld, Carl D, Lehtinen, Allison B, Rudock, Megan E, Lenchik, Leon, Hruska, Keith A, Register, Thomas C, Carr, J Jeffrey
• Format: Journal Article
• Language: English
• Published: Washington, DC John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 01.10.2009; Wiley; Amer Soc Bone & Mineral Res
• Subjects: Biological and medical sciences; Blood Vessels - pathology; Blood Vessels - physiopathology; BMD; BMP2; BMP4; BMP7; Bone Density - genetics; Bone Density - physiology; Bone Morphogenetic Protein 2 - genetics; Bone Morphogenetic Protein 4 - genetics; Bone Morphogenetic Protein 7 - genetics; calcified atherosclerotic plaque; Calcinosis - complications; Calcinosis - genetics; Calcinosis - physiopathology; Demography; diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - physiopathology; European Continental Ancestry Group - genetics; Female; Fundamental and applied biological sciences. Psychology; Genetic Predisposition to Disease; Heart - physiopathology; Humans; Linkage Disequilibrium - genetics; Male; Middle Aged; Original; osteoporosis; Polymorphism, Single Nucleotide - genetics; Principal Component Analysis; Skeleton and joints; Vertebrates: osteoarticular system, musculoskeletal system; Endocrinopathy; Heart; calcified atherosclerotic plaque; Diabetes mellitus; Diseases of the osteoarticular system; Cardiovascular disease; BMP7; Vascular disease; Osteoarticular system; BMP4; Osteoporosis; Vertebrata; BMP2; Mammalia; Bone morphogenetic protein; Gene; Atherosclerotic plaque; Atherosclerosis; Calcification; BMD; Circulatory system; Polymorphism

Inverse relationships have been observed between BMD and vascular calcification (VC), suggesting an underlying metabolic pathway linking these processes. Bone morphogenetic proteins (BMPs) are potential candidate genes that may mediate this relationship. Four single nucleotide polymorphisms (SNPs) i...