Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction

• Published in: Circulation research Vol. 120; no. 7; pp. 1151 - 1161
• Main Authors: Zamani, Payman, Tan, Victor, Soto-Calderon, Haideliza, Beraun, Melissa, Brandimarto, Jeffrey A., Trieu, Lien, Varakantam, Swapna, Doulias, Paschalis-Thomas, Townsend, Raymond R., Chittams, Jesse, Margulies, Kenneth B., Cappola, Thomas P., Poole, David C., Ischiropoulos, Harry, Chirinos, Julio A.
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 31.03.2017; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Aged; Blood pressure; Cardiomyopathy; Chlorides; Clinical trials; Exercise; Female; Heart diseases; Heart failure; Heart Failure - diagnosis; Heart Failure - drug therapy; Heart Failure - rehabilitation; Humans; Hypotension; Male; Metabolites; Methemoglobinemia; Middle Aged; Nitrates - adverse effects; Nitrates - pharmacokinetics; Nitric oxide; Pharmacodynamics; Pharmacokinetics; Potassium; Potassium chloride; Potassium Compounds - adverse effects; Potassium Compounds - pharmacokinetics; Potassium nitrate; Quality of Life; Stroke Volume; Kansas City Missouri; exercise capacity; heart failure; nitric oxide

RATIONALE:Nitrate-rich beetroot juice has been shown to improve exercise capacity in heart failure with preserved ejection fraction, but studies using pharmacological preparations of inorganic nitrate are lacking. OBJECTIVES:To determine (1) the dose–response effect of potassium nitrate (KNO3) on ex...