Race- and gender-related variation in natural killer p46 expression associated with differential anti-hepatitis c virus immunity

• Published in: Hepatology (Baltimore, Md.) Vol. 56; no. 4; pp. 1214 - 1222
• Main Authors: Golden-Mason, Lucy, Stone, Amy E.L., Bambha, Kiran M., Cheng, Linling, Rosen, Hugo R.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2012; Wiley; Wolters Kluwer Health, Inc
• Subjects: Adult; Apoptosis - genetics; Biological and medical sciences; Black or African American - genetics; Case-Control Studies; Cells, Cultured; Cytokines; Cytotoxicity; Cytotoxicity, Immunologic - genetics; Cytotoxicity, Immunologic - immunology; Disease Progression; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gender; Gene expression; Gene Expression Regulation, Viral; Hepacivirus - genetics; Hepacivirus - immunology; Hepatitis; Hepatitis C; Hepatitis C virus; Hepatitis C, Chronic - ethnology; Hepatitis C, Chronic - genetics; Hepatitis C, Chronic - immunology; Hepatocytes - immunology; Hepatocytes - physiology; Hepatology; Humans; Immunity, Innate - genetics; Immunity, Innate - immunology; Infections; Interferon-gamma - genetics; Interferon-gamma - immunology; Ligands; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Natural Cytotoxicity Triggering Receptor 1 - genetics; Natural Cytotoxicity Triggering Receptor 1 - immunology; Race; Real-Time Polymerase Chain Reaction; Reference Values; Sensitivity and Specificity; Sex Factors; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; White People - genetics; Young Adult; Virus; Gastroenterology; Race; Sex; Flaviviridae; Hepatitis C virus; Epidemiology; Hepacivirus; Immunity

Major racial and gender differences have been documented in the natural history and treatment responses of chronic hepatitis C virus (HCV) infection; however, distinct mechanisms have remained enigmatic. We hypothesized that racial‐ and gender‐related differences in natural killer (NK) cell populati...