Immunohistochemical detection of p53 in archival formalin-fixed tissues of lip and intraoral squamous cell carcinomas from Norway

• Published in: APMIS : acta pathologica, microbiologica et immunologica Scandinavica Vol. 105; no. 7-12; pp. 757 - 764
• Main Authors: IBRAHIM, SALAH O., JOHANNESSEN, ANNE C., VASSTRAND, ENDRE N., LILLEHAUG, JOHAN R., NILSEN, RUNE
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.1997; Blackwell
• Subjects: Adult; Aged; Antibodies, Monoclonal; Biological and medical sciences; Carcinoma, Squamous Cell - chemistry; Ent. Stomatology; enzyme predigestion; Female; Fixatives; Formaldehyde; Humans; Immunohistochemistry; Investigative techniques, diagnostic techniques (general aspects); Lip Neoplasms - chemistry; Male; Medical sciences; microwave oven heating; Middle Aged; Mouth Neoplasms - chemistry; Norway; oral squamous cell carcinomas; p53 protein; Paraffin; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Time Factors; Tumor Suppressor Protein p53 - analysis; Norway; Human; Immunohistochemistry; Skin disease; Squamous cell carcinoma; Archive; Stomatology; Malignant tumor; Pathology; Histological fixation; Lip; TP53 Gene; Histopathology; Oral cavity disease; Tumor suppressor gene

We investigated the expression of p53 in 82 formalin‐fixed, paraffin‐embedded archival tissue specimens of lip and intraoral squamous cell carcinomas (SCCs) from the period 1930–1995, by immunohistochemistry using three monoclonal antibodies (MAbs DO‐7, DO‐1 and 1801). Before incubation, sections we...