Multiple system atrophy: genetic risks and alpha-synuclein mutations

• Published in: F1000 research Vol. 6; p. 2072
• Main Authors: Whittaker, Heather T, Qui, Yichen, Bettencourt, Conceição, Houlden, Henry
• Format: Journal Article
• Language: English
• Published: England Faculty of 1000 Ltd 2017; F1000 Research Limited; F1000 Research Ltd
• Subjects: Atrophy; Biomarkers; Brain research; Clinical trials; Dementia; Disease; Genes; Hypotheses; Inclusion bodies; Medical Genetics; Motor Systems; Movement Disorders; Mutation; Neurobiology of Disease & Regeneration; Neurodegeneration; Neurodegenerative diseases; Neurogenetics; Neurology; Neuromuscular diseases; Neuronal Signaling Mechanisms; Neuropathology; Pathology; Patients; Protein folding; Proteins; Review; Studies; Synuclein; MSA; multiple system atrophy; neurodegenerative disorders; α-synuclein

Multiple system atrophy (MSA) is one of the few neurodegenerative disorders where we have a significant understanding of the clinical and pathological manifestations but where the aetiology remains almost completely unknown. Research to overcome this hurdle is gaining momentum through international...