Five-Year Analysis of the Prevention of Colorectal Sporadic Adenomatous Polyps Trial

• Published in: The American journal of gastroenterology Vol. 106; no. 6; pp. 1135 - 1146
• Main Authors: Arber, Nadir, Spicak, Julius, Rácz, István, Zavoral, Miroslav, Breazna, Aurora, Gerletti, Paola, Lechuga, Maria J, Collins, Neal, Rosenstein, Rebecca B, Eagle, Craig J, Levin, Bernard
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.06.2011; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Adenomatous Polyposis Coli - drug therapy; Adenomatous Polyposis Coli - prevention & control; Administration, Oral; Age Factors; Aged; Aged, 80 and over; Aspirin - therapeutic use; Biological and medical sciences; Colonoscopy - methods; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - prevention & control; Confidence Intervals; Cyclooxygenase 2 Inhibitors - therapeutic use; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Israel; Linear Models; Male; Medical sciences; Middle Aged; Neoplasm Invasiveness - pathology; Neoplasm Recurrence, Local; Neoplasm Staging; Risk Assessment; Sex Factors; Statistics, Nonparametric; Time Factors; Treatment Outcome; Israel; Prevention; Adenomatous polyp; Colon; Sporadic; Gastroenterology; Rectum

Subjects in the Prevention of Colorectal Sporadic Adenomatous Polyps (PreSAP) trial (PRESAP/NCT00141193/www.clinicaltrials.gov) were studied to determine efficacy and safety at a year 5 assessment. In this randomized, placebo-controlled, double-blind trial, 1,561 subjects with diagnosed colorectal a...