Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells

• Published in: Biochemical and biophysical research communications Vol. 478; no. 2; pp. 716 - 720
• Main Authors: Thon, Mina, Hosoi, Toru, Ozawa, Koichiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.09.2016
• Subjects: ascorbic acid; Cell Line, Tumor; dehydroascorbic acid; Dehydroascorbic acid (DHAA); Dehydroascorbic Acid - pharmacology; diabetes; endoplasmic reticulum; Endoplasmic reticulum (ER) stress; Endoplasmic Reticulum - drug effects; Endoplasmic Reticulum - metabolism; endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; Gene Expression Regulation; genes; Heat-Shock Proteins - genetics; Heat-Shock Proteins - metabolism; human cell lines; Humans; Leptin; Leptin - genetics; Leptin - metabolism; Leptin - pharmacology; leptin receptors; Leptin resistance; neurons; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; obesity; oxidation; Oxidation-Reduction; pathophysiology; phosphorylation; Phosphorylation - drug effects; Signal Transduction; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Transcription Factor CHOP - genetics; Transcription Factor CHOP - metabolism; Unfolded protein response (UPR); Unfolded Protein Response - drug effects; X-Box Binding Protein 1 - genetics; X-Box Binding Protein 1 - metabolism; AA; XBP1; Endoplasmic reticulum (ER) stress; GRP78; PERK; ER; Dehydroascorbic acid (DHAA); Leptin resistance; Leptin; UPR; IRE1; CHOP; IB; DHAA; ATF6; Unfolded protein response (UPR)

Due to its anti-obesity effects, an adipocyte-derived hormone, leptin, has become important for the treatment of obesity. However, most obese subjects are in a state of leptin resistance, and endoplasmic reticulum (ER) stress is suggested to be involved in the pathophysiology of leptin resistance. D...