Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells - Thon, Mina; Hosoi, Toru; Ozawa, Koichiro (Biochemical and biophysical research communications, 2016)
Keywords: ascorbic acid; Cell Line, Tumor; dehydroascorbic acid; Dehydroascorbic acid (DHAA); Dehydroascorbic Acid - pharmacology; diabetes; endoplasmic reticulum; Endoplasmic reticulum (ER) stress; Endoplasmic Reticulum - drug effects; Endoplasmic Reticulum - metabolism; endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; Gene Expression Regulation; genes; Heat-Shock Proteins - genetics; Heat-Shock Proteins - metabolism; human cell lines; Humans; Leptin; Leptin - genetics; Leptin - metabolism; Leptin - pharmacology; leptin receptors; Leptin resistance; neurons; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; obesity; oxidation; Oxidation-Reduction; pathophysiology; phosphorylation; Phosphorylation - drug effects; Signal Transduction; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Transcription Factor CHOP - genetics; Transcription Factor CHOP - metabolism; Unfolded protein response (UPR); Unfolded Protein Response - drug effects; X-Box Binding Protein 1 - genetics; X-Box Binding Protein 1 - metabolism; AA; XBP1; Endoplasmic reticulum (ER) stress; GRP78; PERK; ER; Dehydroascorbic acid (DHAA); Leptin resistance; Leptin; UPR; IRE1; CHOP; IB; DHAA; ATF6; Unfolded protein response (UPR)