TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes

• Published in: Cell Vol. 184; no. 3; pp. 827 - 839.e14
• Main Authors: Japp, Alberto Sada, Meng, Wenzhao, Rosenfeld, Aaron M., Perry, Daniel J., Thirawatananond, Puchong, Bacher, Rhonda L., Liu, Chengyang, Gardner, Jay S., Atkinson, Mark A., Kaestner, Klaus H., Brusko, Todd M., Naji, Ali, Luning Prak, Eline T., Betts, Michael R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.02.2021
• Subjects: B-Lymphocytes; Clone Cells; Diabetes Mellitus, Type 1 - genetics; Flow Cytometry; HIRN; HPAP; Human Islet Research Network; Human Pancreas Analysis Program; Humans; immune repertoire; immunoglobulin; immunophenotyping; insulin-dependent diabetes mellitus; public clone; rare-event detection; Receptors, Antigen, T-Cell; T-lymphocytes; T1D; type 1 diabetes; type 1 diabetes; immune repertoire; immunoglobulin; immunophenotyping; HPAP; T1D; Human Pancreas Analysis Program; public clone; Human Islet Research Network; HIRN; rare-event detection

Ahmed and colleagues recently described a novel hybrid lymphocyte expressing both a B and T cell receptor, termed double expresser (DE) cells. DE cells in blood of type 1 diabetes (T1D) subjects were present at increased numbers and enriched for a public B cell clonotype. Here, we attempted to repro...