Inflamed moods: A review of the interactions between inflammation and mood disorders

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 53; pp. 23 - 34
• Main Authors: Rosenblat, Joshua D., Cha, Danielle S., Mansur, Rodrigo B., McIntyre, Roger S.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 04.08.2014; Elsevier
• Subjects: Adult and adolescent clinical studies; Animals; Biogenic Monoamines - metabolism; Biological and medical sciences; Bipolar disorder; Bipolar disorders; Cytokines; Cytokines - metabolism; Depression; Humans; Inflammation; Inflammation - complications; Inflammation - metabolism; Major depressive disorder; Medical sciences; Mood disorder; Mood disorders; Mood Disorders - complications; Mood Disorders - metabolism; Neuropharmacology; Non-steroidal anti-inflammatory drug (NSAID); Pharmacology. Drug treatments; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; CRP; BD; SSRIs; NSAID; ACTH; Bipolar disorder; Non-steroidal anti-inflammatory drug (NSAID); IBD; MDD; SLE; LPS; Major depressive disorder; ASA; IFN; IDO; CSF; PAMPs; COX-1 and COX-2; MAOIs; TDO; WHO; AA; Mood disorder; PGE2; Cytokines; TCAs; cPLA2; Inflammation; O-3 PUFA; RA; 5-HIAA; HPA; CRH; Drug; Interaction; Cytokine; Depression; Review; Non steroidal antiinflammatory agent; Mood

Mood disorders have been recognized by the World Health Organization (WHO) as the leading cause of disability worldwide. Notwithstanding the established efficacy of conventional mood agents, many treated individuals continue to remain treatment refractory and/or exhibit clinically significant residu...