Selenium unmasks protective iron armor: A possible defense against cutaneous inflammation and cancer

• Published in: Biochimica et biophysica acta. General subjects Vol. 1862; no. 11; pp. 2518 - 2527
• Main Authors: Arbiser, Jack L., Bonner, Michael Y., Ward, Nicole, Elsey, Justin, Rao, Shikha
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2018
• Subjects: animal models; ant venoms; carcinogenesis; ceramides; cystine; feed supplements; fire ants; gene expression; gene expression regulation; glutamic acid; humans; inflammation; iron; nutrient deficiencies; oxygen; patients; phospholipid-hydroperoxide glutathione peroxidase; psoriasis; reactive oxygen species; selenium; selenoproteins; skin lesions; skin neoplasms; therapeutics; H2AX; Bcl-2; TNFα; SRXN1; GPX1, 2, 3, 5; IL-22; SASP; Txnrd1; S1P; Nrf2; NFKBIZ; COX2; CHAC1; BOK; TFRC or TFR1; NQ01; INFɤ; System XC; GPX4; VEGF; HMO1; GSR; SP-1; GRX3; GPX8; SOD2; BAK; CP; Trx1; CsA; TFR2; MTF1; BAX; Nrarp; GCLM; ATF4

A link between selenium deficiency and inflammatory skin diseases have been noted by many, but this link is still not well understood. We have previously studied the efficacy of ceramide analogs, based on the fire ant venom Solenopsin A, against our psoriasis animal model. Treatment of animals with...