Genomic cartography of varicella–zoster virus: A complete genome-based analysis of strain variability with implications for attenuation and phenotypic differences

• Published in: Virology (New York, N.Y.) Vol. 359; no. 2; pp. 447 - 458
• Main Authors: Tyler, S.D, Peters, G.A, Grose, C, Severini, A, Gray, M.J, Upton, C, Tipples, G.A
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.03.2007
• Subjects: Base Sequence; Genetic Variation; Genome, Viral; Genomics; Genotype; Herpesvirus 3, Human - classification; Herpesvirus 3, Human - genetics; Herpesvirus 3, Human - immunology; Infectious Disease; Molecular Sequence Data; Open Reading Frames; Phenotype; Phylogeny; Recombination; Vaccines, Attenuated - immunology; Varicella-zoster virus; Viral Proteins - genetics; Viral Proteins - metabolism; Viral Vaccines - immunology; VZV; Genotype; Recombination; VZV; Varicella-zoster virus; Phylogeny; Genomics

Abstract In order to gain a better perspective on the true variability of varicella–zoster virus (VZV) and to catalogue the location and number of differences, 11 new complete genome sequences were compared with those previously in the public domain (18 complete genomes in total). Three of the newly...