Induction of CD8 T-cell-Ifn-γ response and positive clinical outcome after immunization with gene-modified allogeneic tumor cells in advanced non-small-cell lung carcinoma

• Published in: Cancer gene therapy Vol. 10; no. 11; pp. 850 - 858
• Main Authors: Raez, Luis E, Cassileth, Peter A, Schlesselman, James J, Padmanabhan, Swaminathan, Fisher, Eva Z, Baldie, Paulette A, Sridhar, Kasi, Podack, Eckhard R
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.11.2003; Nature Publishing Group
• Subjects: Adult; B7-1 Antigen - genetics; B7-1 Antigen - immunology; Biomedical and Life Sciences; Biomedicine; Cancer Vaccines - adverse effects; Cancer Vaccines - immunology; Carcinoma, Non-Small-Cell Lung - immunology; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - therapy; Care and treatment; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; CD80 antigen; Dosage and administration; Effector cells; Gene Expression; Gene Therapy; Genetic aspects; Glycoproteins; Health aspects; Histocompatibility antigen HLA; HLA-A1 Antigen - genetics; HLA-A1 Antigen - immunology; HLA-A2 Antigen - genetics; HLA-A2 Antigen - immunology; Humans; Immunization; Immunotherapy, Adoptive - methods; Interferon gamma; Interferon-gamma - immunology; Interferon-gamma - metabolism; Lung cancer; Lung cancer, Non-small cell; Lung carcinoma; Lung Neoplasms - immunology; Lung Neoplasms - pathology; Lung Neoplasms - therapy; Lymphocytes T; Non-small cell lung carcinoma; original-article; Patients; Transfection; Treatment Outcome; Tumor cells; Tumor Cells, Cultured; Tumors; γ-Interferon; United States
• ISSN: 0929-1903; 1476-5500
• DOI: 10.1038/sj.cgt.7700641

Large tumor burdens in advanced non-small-cell lung carcinoma (NSCLC) are thought to be immunosuppressive. To determine whether CD8-mediated immune responses could be elicited in stage IIIB/IV NSCLC patients, 14 subjects were immunized several times with allogeneic NSCLC cells transfected with CD80...