Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation

• Published in: British journal of cancer Vol. 103; no. 8; pp. 1192 - 1200
• Main Authors: de Plater, L, Laugé, A, Guyader, C, Poupon, M-F, Assayag, F, de Cremoux, P, Vincent-Salomon, A, Stoppa-Lyonnet, D, Sigal-Zafrani, B, Fontaine, J-J, Brough, R, Lord, C J, Ashworth, A, Cottu, P, Decaudin, D, Marangoni, E
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.10.2010; Nature Publishing Group
• Subjects: 631/208/737; 631/67/1059/153; 692/308/2778; 692/699/67/1347; Adult; Animals; Anthracyclines - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biomedical and Life Sciences; Biomedicine; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cancer Research; Cancer therapies; Carcinoma, Ductal, Breast - drug therapy; Carcinoma, Ductal, Breast - genetics; Carcinoma, Ductal, Breast - pathology; Cell Culture Techniques; Cell Line, Tumor; Comparative Genomic Hybridization; DNA Mutational Analysis; DNA repair; Drug Resistance; Epidemiology; Female; Genes, BRCA2; Genetic testing; Germ-Line Mutation - physiology; Heterozygote; Humans; Medical research; Mice; Mice, Nude; Molecular Medicine; Mutation; Neoplasm Transplantation; Oncology; Ovarian cancer; Translational Therapeutics; Transplantation, Heterologous; Tumors; Womens health; Xenograft Model Antitumor Assays - methods; France; Paris France; BRCA2 mutation; human breast cancer xenograft; preclinical model

Background: The BRCA2 gene is responsible for a high number of hereditary breast and ovarian cancers, and studies of the BRCA2 biological functions are limited by the lack of models that resemble the patient's tumour features. The aim of this study was to establish and characterise a new human...