Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 328; no. 3; pp. 785 - 795
• Main Authors: Threlfell, Sarah, Sammut, Stephen, Menniti, Frank S, Schmidt, Christopher J, West, Anthony R
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.03.2009
• Subjects: Animals; Corpus Striatum - drug effects; Corpus Striatum - physiology; Electric Stimulation; Electrophysiology - methods; Evoked Potentials - drug effects; Evoked Potentials - physiology; Frontal Lobe - drug effects; Frontal Lobe - physiology; Globus Pallidus - drug effects; Globus Pallidus - physiology; Male; Microdialysis; Neurons - drug effects; Neurons - physiology; Neuropharmacology; Papaverine - pharmacology; Phosphodiesterase Inhibitors - pharmacology; Phosphoric Diester Hydrolases - metabolism; Pyramidal Cells - drug effects; Pyramidal Cells - physiology; Rats; Rats, Sprague-Dawley; Signal Transduction - drug effects; Signal Transduction - physiology; Substantia Nigra - drug effects; Substantia Nigra - physiology

The cyclic nucleotide phosphodiesterase 10A (PDE10A) is highly expressed in striatal medium-sized spiny projection neurons (MSNs), apparently playing a critical role in the regulation of both cGMP and cAMP signaling cascades. Genetic disruption or pharmacological inhibition of PDE10A reverses behavi...