Altered functional-structural coupling of large-scale brain networks in idiopathic generalized epilepsy

• Published in: Brain (London, England : 1878) Vol. 134; no. 10; pp. 2912 - 2928
• Main Authors: Zhang, Zhiqiang, Liao, Wei, Chen, Huafu, Mantini, Dante, Ding, Ju-Rong, Xu, Qiang, Wang, Zhengge, Yuan, Cuiping, Chen, Guanghui, Jiao, Qing, Lu, Guangming
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2011
• Subjects: Adolescent; Adult; Biological and medical sciences; Brain - physiopathology; Brain Mapping; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Diffusion Tensor Imaging; Epilepsy, Generalized - physiopathology; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Medical sciences; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Nerve Net - physiopathology; Nervous system (semeiology, syndromes); Neural Pathways - physiopathology; Neurology; Neurons - physiology; Reproducibility of Results; Seizures - physiopathology; idiopathic generalized epilepsy; coupling; functional connectivity network; generalized tonic-clonic seizures; structural connectivity network; Nervous system diseases; Epilepsy; Central nervous system; Idiopathic; Cerebral disorder; Encephalon; Convulsion; Central nervous system disease; Coupling; Neurological disorder

The human brain is a large-scale integrated network in the functional and structural domain. Graph theoretical analysis provides a novel framework for analysing such complex networks. While previous neuroimaging studies have uncovered abnormalities in several specific brain networks in patients with...