The interaction among gut microbes, the intestinal barrier and short chain fatty acids

The mammalian gut is inhabited by a massive and complicated microbial community, in which the host achieves a stable symbiotic environment through the interdependence, coordination, reciprocal constraints and participation in an immune response. The interaction between the host gut and the microbiot...

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Published inAnimal Nutrition Vol. 9; pp. 159 - 174
Main Authors Ma, Jiayu, Piao, Xiangshu, Mahfuz, Shad, Long, Shenfei, Wang, Jian
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 01.06.2022
KeAi Publishing
KeAi Communications Co., Ltd
Subjects
animal nutrition
energy
feedstocks
growth and development
Gut microbiota
homeostasis
immune response
Interaction mechanism
Intestinal barrier
Intestinal epithelium cells
mammals
metabolites
microbial communities
Review
Short chain fatty acids
Gut microbiota
Intestinal barrier
Interaction mechanism
Intestinal epithelium cells
Short chain fatty acids
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Abstract The mammalian gut is inhabited by a massive and complicated microbial community, in which the host achieves a stable symbiotic environment through the interdependence, coordination, reciprocal constraints and participation in an immune response. The interaction between the host gut and the microbiota is essential for maintaining and achieving the homeostasis of the organism. Consequently, gut homeostasis is pivotal in safeguarding the growth and development and potential productive performance of the host. As metabolites of microorganisms, short chain fatty acids are not only the preferred energy metabolic feedstock for host intestinal epithelial cells, but also exert vital effects on antioxidants and the regulation of intestinal community homeostasis. Herein, we summarize the effects of intestinal microorganisms on the host gut and the mechanisms of action of short chain fatty acids on the four intestinal barriers of the organism, which will shed light on the manipulation of the intestinal community to achieve precise nutrition for specific individuals and provide a novel perspective for the prevention and treatment of diseases.
AbstractList The mammalian gut is inhabited by a massive and complicated microbial community, in which the host achieves a stable symbiotic environment through the interdependence, coordination, reciprocal constraints and participation in an immune response. The interaction between the host gut and the microbiota is essential for maintaining and achieving the homeostasis of the organism. Consequently, gut homeostasis is pivotal in safeguarding the growth and development and potential productive performance of the host. As metabolites of microorganisms, short chain fatty acids are not only the preferred energy metabolic feedstock for host intestinal epithelial cells, but also exert vital effects on antioxidants and the regulation of intestinal community homeostasis. Herein, we summarize the effects of intestinal microorganisms on the host gut and the mechanisms of action of short chain fatty acids on the four intestinal barriers of the organism, which will shed light on the manipulation of the intestinal community to achieve precise nutrition for specific individuals and provide a novel perspective for the prevention and treatment of diseases.
The mammalian gut is inhabited by a massive and complicated microbial community, in which the host achieves a stable symbiotic environment through the interdependence, coordination, reciprocal constraints and participation in an immune response. The interaction between the host gut and the microbiota is essential for maintaining and achieving the homeostasis of the organism. Consequently, gut homeostasis is pivotal in safeguarding the growth and development and potential productive performance of the host. As metabolites of microorganisms, short chain fatty acids are not only the preferred energy metabolic feedstock for host intestinal epithelial cells, but also exert vital effects on antioxidants and the regulation of intestinal community homeostasis. Herein, we summarize the effects of intestinal microorganisms on the host gut and the mechanisms of action of short chain fatty acids on the four intestinal barriers of the organism, which will shed light on the manipulation of the intestinal community to achieve precise nutrition for specific individuals and provide a novel perspective for the prevention and treatment of diseases.The mammalian gut is inhabited by a massive and complicated microbial community, in which the host achieves a stable symbiotic environment through the interdependence, coordination, reciprocal constraints and participation in an immune response. The interaction between the host gut and the microbiota is essential for maintaining and achieving the homeostasis of the organism. Consequently, gut homeostasis is pivotal in safeguarding the growth and development and potential productive performance of the host. As metabolites of microorganisms, short chain fatty acids are not only the preferred energy metabolic feedstock for host intestinal epithelial cells, but also exert vital effects on antioxidants and the regulation of intestinal community homeostasis. Herein, we summarize the effects of intestinal microorganisms on the host gut and the mechanisms of action of short chain fatty acids on the four intestinal barriers of the organism, which will shed light on the manipulation of the intestinal community to achieve precise nutrition for specific individuals and provide a novel perspective for the prevention and treatment of diseases.
Author Wang, Jian
Mahfuz, Shad
Long, Shenfei
Ma, Jiayu
Piao, Xiangshu
Author_xml – sequence: 1
  givenname: Jiayu
  surname: Ma
  fullname: Ma, Jiayu
  organization: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
– sequence: 2
  givenname: Xiangshu
  orcidid: 0000-0001-5913-8889
  surname: Piao
  fullname: Piao, Xiangshu
  email: piaoxsh@cau.edu.cn
  organization: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
– sequence: 3
  givenname: Shad
  surname: Mahfuz
  fullname: Mahfuz, Shad
  organization: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
– sequence: 4
  givenname: Shenfei
  surname: Long
  fullname: Long, Shenfei
  organization: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
– sequence: 5
  givenname: Jian
  surname: Wang
  fullname: Wang, Jian
  organization: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35573092$$D View this record in MEDLINE/PubMed
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Copyright 2022 Chinese Association of Animal Science and Veterinary Medicine
2022 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
2022 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. 2022 Chinese Association of Animal Science and Veterinary Medicine
Copyright_xml – notice: 2022 Chinese Association of Animal Science and Veterinary Medicine
– notice: 2022 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
– notice: 2022 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. 2022 Chinese Association of Animal Science and Veterinary Medicine
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Tue Jul 01 02:34:51 EDT 2025
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Keywords Gut microbiota
Intestinal barrier
Interaction mechanism
Intestinal epithelium cells
Short chain fatty acids
Language English
License This is an open access article under the CC BY-NC-ND license.
2022 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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Snippet The mammalian gut is inhabited by a massive and complicated microbial community, in which the host achieves a stable symbiotic environment through the...
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SubjectTerms animal nutrition
energy
feedstocks
growth and development
Gut microbiota
homeostasis
immune response
Interaction mechanism
Intestinal barrier
Intestinal epithelium cells
mammals
metabolites
microbial communities
Review
Short chain fatty acids
Title The interaction among gut microbes, the intestinal barrier and short chain fatty acids
URI https://dx.doi.org/10.1016/j.aninu.2021.09.012
https://www.ncbi.nlm.nih.gov/pubmed/35573092
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Volume 9
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