Molecular Definition of a Novel Human Galectin Which Is Immunogenic in Patients with Hodgkin's Disease

• Published in: The Journal of biological chemistry Vol. 272; no. 10; pp. 6416 - 6422
• Main Authors: Türeci, Özlem, Schmitt, Holger, Fadle, Natalie, Pfreundschuh, Michael, Sahin, Ugur
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.03.1997; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Cloning, Molecular; Cricetinae; DNA, Complementary - genetics; Galectins; Gene Expression; Hodgkin Disease - immunology; Humans; Lactose - metabolism; Lectins - genetics; Lectins - immunology; Leukocytes - metabolism; Molecular Sequence Data; Rats; Restriction Mapping; Sequence Alignment; Sequence Homology, Amino Acid

Using autologous serum for the immunoscreening of a cDNA expression library derived from tissue involved by Hodgkin's disease, a new 36-kDa protein with the characteristics of galectins (S-type lectins) was detected. Sequence analysis of the cDNA clone HOM-HD-21 revealed two homologous motifs k...