A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci

• Published in: Human molecular genetics Vol. 19; no. 11; pp. 2303 - 2312
• Main Authors: Okada, Yukinori, Kamatani, Yoichiro, Takahashi, Atsushi, Matsuda, Koichi, Hosono, Naoya, Ohmiya, Hiroko, Daigo, Yataro, Yamamoto, Kazuhiko, Kubo, Michiaki, Nakamura, Yusuke, Kamatani, Naoyuki
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.06.2010
• Subjects: Adult; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Body Height - genetics; European Continental Ancestry Group - genetics; Fundamental and applied biological sciences. Psychology; Gene Frequency; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Homeodomain Proteins - genetics; Humans; Insulin-Like Growth Factor I - genetics; LIM-Homeodomain Proteins; Molecular and cellular biology; Oxidoreductases Acting on Sulfur Group Donors - genetics; Polymorphism, Single Nucleotide - genetics; Transcription Factors; Human; Association; Adult; Genetics; Insulin like growth factor 1; Locus; Japanese

Previous genome-wide association studies (GWASs) have identified several loci associated with human height; however, such evidence was mostly reported in Caucasian populations. Since the different distributions of height between populations suggest their different genetic backgrounds, analysis in di...