Genome-wide Association Study of Susceptibility Loci for Cervical Cancer

• Published in: JNCI : Journal of the National Cancer Institute Vol. 105; no. 9; pp. 624 - 633
• Main Authors: Chen, Dan, Juko-Pecirep, Ivana, Hammer, Joanna, Ivansson, Emma, Enroth, Stefan, Gustavsson, Inger, Feuk, Lars, Magnusson, Patrik K.E., McKay, James D., Wilander, Erik, Gyllensten, Ulf
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 01.05.2013; Oxford Publishing Limited (England)
• Subjects: Adult; Aged; Biological and medical sciences; Case-Control Studies; Cervical cancer; Female; Female genital diseases; Gene loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Genomes; Gynecology. Andrology. Obstetrics; Histocompatibility Antigens - genetics; Histocompatibility Antigens Class I - genetics; HLA-DP beta-Chains - genetics; HLA-DQ alpha-Chains - genetics; HLA-DRB1 Chains - genetics; Humans; Leukocytes; Logistic Models; Medical sciences; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Odds Ratio; Polymorphism; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Sweden - epidemiology; Tumors; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - genetics; Womens health; Sweden; Human; Cancerology; Predisposition; Genetics; Malignant tumor; Genome; Locus; Uterine cervix diseases; Cervical cancer; Cancer; Female genital diseases

Cervical carcinoma has a heritable genetic component, but the genetic basis of cervical cancer is still not well understood. We performed a genome-wide association study of 731 422 single nucleotide polymorphisms (SNPs) in 1075 cervical cancer case subjects and 4014 control subjects and replicated i...