Human transcriptomic response to periprosthetic joint infection

• Published in: Gene Vol. 825; p. 146400
• Main Authors: Masters, Thao L., Bhagwate, Aditya V., Dehankar, Mrunal K., Greenwood-Quaintance, Kerryl E., Abdel, Matthew P., Mandrekar, Jay N., Patel, Robin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.05.2022
• Subjects: Arthritis, Infectious - diagnosis; Arthritis, Infectious - metabolism; Arthritis, Infectious - microbiology; B-lymphocytes; Biomarkers; Biomarkers - analysis; cathelicidins; coagulation; Colony-Stimulating Factors; gene expression; gene expression regulation; genes; Host response; Humans; immune response; intercellular adhesion molecule-1; interferon-gamma; interleukin-1; interleukin-13; interleukin-2; interleukin-5; interleukin-6; Interleukin-8; lactate dehydrogenase; Ligands; lipopolysaccharides; maintenance and repair; Matrix Metalloproteinase 3 - metabolism; pathogenesis; Periprosthetic joint infection; permeability; Prosthesis-Related Infections - diagnosis; Prosthesis-Related Infections - genetics; proteinase inhibitors; RNA-Seq; Sonicate fluid; Staphylococcal Infections - microbiology; Staphylococcus aureus; Staphylococcus aureus - metabolism; Staphylococcus epidermidis; Synovial Fluid - metabolism; Transcriptome; transcriptomics; Vascular Endothelial Growth Factor A; Host response; Sonicate fluid; Biomarkers; Periprosthetic joint infection; RNA-Seq

•Host transcriptomic analysis confirmed 28 previously reported biomarkers of PJI.•3 novel genes have potential diagnostic use for PJI detection-CCL20, F7, and FCRL4.•IL13, IL17D, and MMP3 are highly expressed in staphylococcal PJI.•IL1B, IL8, and PF4V1 could differentiate S. aureus from S. epidermid...