Lyophilization of a triply unsaturated phospholipid: Effects of trace metal contaminants

• Published in: European journal of pharmaceutics and biopharmaceutics Vol. 85; no. 2; pp. 306 - 313
• Main Authors: Payton, N.M., Wempe, M.F., Betker, J.L., Randolph, T.W., Anchordoquy, T.J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2013
• Subjects: Buffers; Carbohydrates - chemistry; Chemical stability; DLPC; Drug Contamination; Ferrous Compounds - chemistry; Freeze Drying - methods; Freeze-drying; Freezing; Lipids - chemistry; Liposomes; Lyophilization; Metal contamination; Metals - chemistry; Osmolar Concentration; Oxidation; Phosphatidylcholines - chemistry; Phospholipids - chemistry; Sucrose - chemistry; Sulfites - chemistry; Trace Elements - chemistry; Unsaturated lipids; Chemical stability; Oxidation; DLPC; Lyophilization; Liposomes; Metal contamination; Unsaturated lipids; Freezing; Freeze-drying

As liquid liposomal formulations are prone to chemical degradation and aggregation, these formulations often require freeze drying (e.g., lyophilization) to achieve sufficient shelf-life. However, liposomal formulations may undergo oxidation during lyophilization and/or during prolonged storage. The...