Use of Metagenomic Next-Generation Sequencing to Identify Pathogens in Pediatric Osteoarticular Infections

• Published in: Open forum infectious diseases Vol. 8; no. 7; p. ofab346
• Main Authors: Ramchandar, Nanda, Burns, Jessica, Coufal, Nicole G, Pennock, Andrew, Briggs, Benjamin, Stinnett, Rita, Bradley, John, Arnold, John, Liu, George Y, Pring, Maya, Upasani, Vidyadhar V, Rickert, Kathleen, Dimmock, David, Chiu, Charles, Farnaes, Lauge, Cannavino, Christopher
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.07.2021
• Subjects: Arthritis; Major; Pathogens; Pediatrics; osteomyelitis; septic arthritis; next-generation sequencing; metagenomics; mNGS

Abstract Background Osteoarticular infections (OAIs) are frequently encountered in children. Treatment may be guided by isolation of a pathogen; however, operative cultures are often negative. Metagenomic next-generation sequencing (mNGS) allows for broad and sensitive pathogen detection that is cul...