Mutation analysis of vinyl carbamate or urethane induced lung tumors in rasH2 transgenic mice

• Published in: Toxicology letters Vol. 142; no. 1; pp. 111 - 117
• Main Authors: Tomisawa, Masashi, Suemizu, Hiroshi, Ohnishi, Yasuyuki, Maruyama, Chika, Urano, Kohji, Usui, Toshimi, Yasuhara, Kazuo, Tamaoki, Norikazu, Mitsumori, Kunitoshi
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 30.04.2003; Amsterdam Elsevier Science
• Subjects: Animals; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens - toxicity; Chemical agents; Codon; Crosses, Genetic; Female; Genes, ras - genetics; Human c-Ha- ras gene; Lung Neoplasms - chemically induced; Lung Neoplasms - genetics; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single-Stranded Conformational; rasH2 transgenic mouse; RNA, Neoplasm - chemistry; RNA, Neoplasm - genetics; Tumors; Urethane; Urethane - analogs & derivatives; Urethane - toxicity; Vinyl carbamate; Vinyl carbamate; Urethane; Mutation; rasH2 transgenic mouse; Human c-Ha- ras gene; Lung disease; Respiratory disease; Rodentia; Transgenic animal; Malignant tumor; Organic carbamate; Carcinogen; Vertebrata; Mammalia; Mouse; Human c-Ha-ras gene

Previous studies showed that significant differences in mutation frequency of the human c-Ha- ras transgene between vinyl carbamate (VC)- and ethyl carbamate (urethane)-induced lung tumors were observed in rasH2 mice. It remains unclear why the point mutation frequency is extremely low in VC-induced...