ESCRT-III–dependent membrane repair blocks ferroptosis

• Published in: Biochemical and biophysical research communications Vol. 522; no. 2; pp. 415 - 421
• Main Authors: Dai, Enyong, Meng, Lingjun, Kang, Rui, Wang, Xiaofeng, Tang, Daolin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.02.2020
• Subjects: Animals; calcium; Calcium - metabolism; Cell Line, Tumor; Cell Membrane - metabolism; cell viability; DAMP; endoplasmic reticulum stress; Endosomal Sorting Complexes Required for Transport - genetics; Endosomal Sorting Complexes Required for Transport - metabolism; ESCRT; Ferroptosis; Humans; Lipid peroxidation; lipids; Membrane repair; Mice, Nude; neoplasm cells; plasma membrane; NFE2L2/NRF2; ESCRT; GPX4; HSPA5; MLKL; TUDCA; Lipid peroxidation; EIF2AK3; Ferroptosis; HMGB1; MDA; SLC7A11; DAMPs; RCD; CHMP; Membrane repair; DAMP

Ferroptosis is a form of regulated cell death that is triggered by iron accumulation and lipid peroxidation. Although plasma membrane injuries represent an important event in cell death, the impact of membrane repair mechanisms on ferroptosis remains unidentified. Here, we provide the first evidence...