Higher than expected carrier rates for familial Mediterranean fever in various Jewish ethnic groups

• Published in: European journal of human genetics : EJHG Vol. 8; no. 4; pp. 307 - 310
• Main Authors: Stoffman, N, Magal, N, Shohat, T, Lotan, R, Koman, S, Oron, A, Danon, Y, Halpern, G J, Lifshitz, Y, Shohat, M
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.04.2000
• Subjects: Adult; Africa, Northern - ethnology; Alleles; Amino Acid Substitution; Amyloidosis; Consortia; Cytoskeletal Proteins; Familial Mediterranean fever; Familial Mediterranean Fever - ethnology; Familial Mediterranean Fever - genetics; Fever; Genetics; Heterozygote; Heterozygotes; Homozygotes; Humans; Iran - ethnology; Iraq - ethnology; Israel; Jewish people; Jews - genetics; Minority & ethnic groups; Mutation; Phenotypes; Proteins - genetics; Pyrin; Pyrin protein; Renal failure; Israel; Iraq

Familial Mediterranean fever (FMF) is an autosomal recessive disease characterised by recurrent attacks of inflammation of serosal membranes. Amyloidosis leading to renal failure is the most severe complication in untreated patients. In Israel FMF is most frequent among Jews of North African origin....