Synthesis of a stable and orally bioavailable englerin analogue - Fash, David M.; Peer, Cody J.; Li, Zhenwu; Talisman, Ian J.; Hayavi, Sima; Sulzmaier, Florian J.; Ramos, Joe W.; Sourbier, Carole; Neckers, Leonard; Figg, W. Douglas; Beutler, John A.; Chain, William J. (Bioorganic & medicinal chemistry letters, 2016)
Keywords: Administration, Oral; Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Bioavailability; Biological Availability; Cancer; Cell Line, Tumor; Cell Proliferation - drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Englerins; Humans; Mice; Molecular Structure; Rats; Sesquiterpenes; Sesquiterpenes, Guaiane - administration & dosage; Sesquiterpenes, Guaiane - chemistry; Sesquiterpenes, Guaiane - pharmacology; Structure-Activity Relationship; Bioavailability; Englerins; Sesquiterpenes; Cancer