Ubiquitous L1 Mosaicism in Hippocampal Neurons

• Published in: Cell Vol. 161; no. 2; pp. 228 - 239
• Main Authors: Upton, Kyle R., Gerhardt, Daniel J., Jesuadian, J. Samuel, Richardson, Sandra R., Sánchez-Luque, Francisco J., Bodea, Gabriela O., Ewing, Adam D., Salvador-Palomeque, Carmen, van der Knaap, Marjo S., Brennan, Paul M., Vanderver, Adeline, Faulkner, Geoffrey J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.04.2015; Cell Press
• Subjects: genes; Genetic Variation; hippocampus; Hippocampus - cytology; Humans; loci; Long Interspersed Nucleotide Elements; Mosaicism; Neurogenesis; neurons; Neurons - cytology; Polymerase Chain Reaction; probability; retrotransposons; reverse transcription; stem cells; Tissue Banks

Somatic LINE-1 (L1) retrotransposition during neurogenesis is a potential source of genotypic variation among neurons. As a neurogenic niche, the hippocampus supports pronounced L1 activity. However, the basal parameters and biological impact of L1-driven mosaicism remain unclear. Here, we performed...