Comparative genome-wide DNA methylation analysis in myocardial tissue from donors with and without Down syndrome

• Published in: Gene Vol. 764; p. 145099
• Main Authors: Cejas, Romina B., Wang, Jie, Hageman-Blair, Rachael, Liu, Song, Blanco, Javier G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.01.2021
• Subjects: Adult; age; Aged; Aged, 80 and over; architecture; Cardiac methylation; Child; Chromosomes, Human, Pair 21 - genetics; Core Binding Factor Alpha 2 Subunit - genetics; CpG Islands - genetics; DNA; DNA Methylation; Down syndrome; Down Syndrome - genetics; Epigenesis, Genetic; Epigenetics; Epigenomics; Female; gender; gene expression; genes; Genetic Loci - genetics; Heart; Humans; Infant; loci; Male; Middle Aged; Myocardium; Myocardium - metabolism; non-coding RNA; people; phenotype; proteins; Real-Time Polymerase Chain Reaction; regression analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; sampling; Sequence Analysis, DNA; trisomics; Trisomy 21; variability; Young Adult; Heart; RNA; DMR; GO; mRNA; non-DS; ACTB; DS; RUNX1; Trisomy 21; SNP; FDR; DNA; RRBS; Cardiac methylation; Epigenetics; Myocardium; RT-qPCR; PCR; DSCR

•Global DNA methylation is similar in DS and non-DS myocardium.•There is a small number of differentially methylated loci in DS myocardium.•58% of genes overlapping with DMR codify for proteins with known functions. Down syndrome (DS, trisomy 21) is the most common major chromosomal aneuploidy compa...