The Insulin-Like Growth Factor-I Receptor Kinase Inhibitor, NVP-ADW742, Sensitizes Small Cell Lung Cancer Cell Lines to the Effects of Chemotherapy

• Published in: Clinical cancer research Vol. 11; no. 4; pp. 1563 - 1571
• Main Authors: WARSHAMANA-GREENE, G. Sakuntala, LITZ, Julie, BUCHDUNGER, Elisabeth, GARCIA-ECHEVERRIA, Carlos, HOFMANN, Francesco, KRYSTAL, Geoffrey W
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.02.2005
• Subjects: Antineoplastic agents; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Biological and medical sciences; c-Kit; Carboplatin - pharmacology; Carcinoma, Small Cell - drug therapy; Carcinoma, Small Cell - pathology; Cell Division - drug effects; Cell Line, Tumor; Cell Survival - drug effects; chemotherapy; Dose-Response Relationship, Drug; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Etoposide - pharmacology; Gene Expression Regulation, Neoplastic - drug effects; Humans; IGF-I receptor; In Situ Nick-End Labeling; Insulin-Like Growth Factor I - pharmacology; kinase inhibitor; lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Medical sciences; Pharmacology. Drug treatments; Pneumology; Protein Kinase Inhibitors - pharmacology; Protein-Serine-Threonine Kinases - metabolism; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins c-akt; Pyrimidines - pharmacology; Pyrroles - pharmacology; Receptor, IGF Type 1 - antagonists & inhibitors; Receptor, IGF Type 1 - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Tumors of the respiratory system and mediastinum; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; Antineoplastic agent; Lung disease; Respiratory disease; Enzyme; Transferases; Bonchopulmonary small cell carcinoma; Lung cancer; Malignant tumor; Insulin like growth factor 1; In vitro; Chemotherapy; Cell line; Treatment; Kinase; Established cell line; Bronchus disease; Inhibitor; Biological receptor

Purpose: Insulin-like growth factor-I (IGF-I) is a potent growth factor for small cell lung cancer (SCLC) in both the autocrine and endocrine context. It also inhibits chemotherapy-induced apoptosis through activation of the phosphatidylinositol 3-kinase (PI3K)-Akt pathway and we have previously sho...